The DOI matches its Crossref record; 453 of the 453 references it cites were found in a registry or an index.
Sex determination, gonadal sex differentiation, and plasticity in vertebrate species
Abstract
A diverse array of sex determination ( SD) mechanisms, encompassing environmental to genetic, have been found to exist among vertebrates, covering a spectrum from fixed SD mechanisms (mammals) to functional sex change in fishes (sequential hermaphroditic fishes). A major landmark in vertebrate SD was the discovery of the SRY gene in 1990. Since that time, many attempts to clone an SRY ortholog from nonmammalian vertebrates remained unsuccessful, until 2002, when DMY/dmrt1by was discovered as the SD gene of a small fish, medaka. Surprisingly, however, DMY/dmrt1by was found in only 2 species among more than 20 species of medaka, suggesting a large diversity of SD genes among vertebrates. Considerable progress has been made over the last 3 decades, such that it is now possible to formulate reasonable paradigms of how SD and gonadal sex differentiation may work in some model vertebrate species. This review outlines our current understanding of vertebrate SD and gonadal sex differentiation, with a focus on the molecular and cellular mechanisms involved. An impressive number of genes and factors have been discovered that play important roles in testicular and ovarian differentiation. An antagonism between the male and female pathway genes exists in gonads during both sex differentiation and, surprisingly, even as adults, suggesting that, in addition to sex-changing fishes, gonochoristic vertebrates including mice maintain some degree of gonadal sexual plasticity into adulthood. Importantly, a review of various SD mechanisms among vertebrates suggests that this is the ideal biological event that can make us understand the evolutionary conundrums underlying speciation and species diversity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Items 401–453 of 453
Consensus Statement on Terminology and Management: Disorders of Sex Development
Houk, C. P., & Lee, P. A. (2008) · Sexual Development · doi:10.1159/000152032 · Cited by 53
Uno, Y., Nishida, C., Yoshimoto, S., Ito, M., Oshima, Y., Yokoyama, S., Nakamura, M., & Matsuda, Y. (2008) · Chromosome Research · doi:10.1007/s10577-008-1257-z · Cited by 53
Self-citationEpigenetic regulation of male fate commitment from an initially bipotential system
Garcia-Moreno, S. A., Plebanek, M. P., & Capel, B. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.01.009 · Cited by 53
A brief history of sex determination
Stévant, I., Papaioannou, M. D., & Nef, S. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.04.004 · Cited by 53
Yao, H. H., & Capel, B. (2005) · The Journal of Biochemistry · doi:10.1093/jb/mvi097 · Cited by 52
Elzaïat, M., Jouneau, L., Thépot, D., Klopp, C., Allais‐Bonnet, A., Cabau, C., André, M., Chaffaux, S., Cribiu, E.-P., Pailhoux, É., et al. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.122796 · Cited by 51
Matsumoto, Y., Hannigan, B., & Crews, D. (2014) · Endocrinology · doi:10.1210/en.2014-1404 · Cited by 50
Ellegren, H. (2011) · Genome Research · doi:10.1101/gr.119065.110 · Cited by 48
Germ Cells Are Not Required to Establish the Female Pathway in Mouse Fetal Gonads
Maatouk, D. M., Mork, L., Hinson, A., Kobayashi, A., McMahon, A. P., & Capel, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047238 · Cited by 47
FOXL2 antagonises the male developmental pathway in embryonic chicken gonads
Major, A. T., Ayers, K. L., Chue, J., Roeszler, K. N., & Smith, C. A. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0277 · Cited by 47
Crespo, B., Gómez, A., Mazón, M. J., Carrillo, M., & Zanuy, S. (2013) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2013.06.010 · Cited by 46
R-spondin1 tips the balance in sex determination
Capel, B. (2006) · Nature Genetics · doi:10.1038/ng1106-1233 · Cited by 46
Chen, S., Zhang, H., Wang, F., Zhang, W., & Peng, G. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.06.005 · Cited by 46
How does temperature determine sex?
Georges, A., & Holleley, C. E. (2018) · Science · doi:10.1126/science.aat5993 · Cited by 46
Mahawong, P., Sinclair, A. W., Li, Y., et al. (2014) · Differentiation · doi:10.1016/j.diff.2014.09.005 · Cited by 45
Sex-Determining Mechanism in Avians
Kuroiwa, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-3975-1_2 · Cited by 45
Building an Ovary: Insights into Establishment of Somatic Cell Lineages in the Mouse
Nicol, B., & Yao, H. H. (2014) · Sexual Development · doi:10.1159/000358072 · Cited by 44
Zebrafish dax1 Is Required for Development of the Interrenal Organ, the Adrenal Cortex Equivalent
Zhao, Y., Yang, Z., Phelan, J. K., Wheeler, D. A., Lin, S., & McCabe, E. R. B. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0445 · Cited by 42
Medaka : a model for organogenesis, human disease, and evolution
成瀬, 清., Tanaka, M., & 武田, 洋. (2011) · Springer eBooks · Cited by 42
A case of Aromatase deficiency due to a novel CYP19A1 mutation
Gagliardi, L., Scott, H. S., Feng, J., & Torpy, D. J. (2014) · BMC Endocrine Disorders · doi:10.1186/1472-6823-14-16 · Cited by 42
Epigenetic regulation of mammalian sex determination
Kuroki, S., & Tachibana, M. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.12.006 · Cited by 42
Rice, E. S., Kohno, S., John, J. S., Pham, S., Howard, J. M., Lareau, L. F., O’Connell, B. L., Hickey, G., Armstrong, J. C., Deran, A., et al. (2017) · Genome Research · doi:10.1101/gr.213595.116 · Cited by 42
Sakurai, N., Maruo, K., Haraguchi, S., Uno, Y., Oshima, Y., Tsutsui, K., Matsuda, Y., do Rego, J. L., Pelletier, G., Vaudry, H., et al. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.07.002 · Cited by 41
Self-citationMolecular evidence for sex reversal in wild populations of green frogs ( Rana clamitans )
Lambert, M. R., Tran, T., Kilian, A., Ezaz, T., & Skelly, D. K. (2019) · PeerJ · doi:10.7717/peerj.6449 · Cited by 40
Marino, R. M., Garrido, N. P., Costanzo, M., Guercio, G., Juanes, M., Rocco, C. A., Ramírez, P., Warman, D. M., Ciaccio, M., Pena, G., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2967 · Cited by 38
Translating genomics to the clinical diagnosis of disorders/differences of sex development
Parivesh, A., Barseghyan, H., Délot, E. C., & Vilain, E. J. N. (2019) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2019.01.005 · Cited by 38
Mitotic Arrest in Teratoma Susceptible Fetal Male Germ Cells
Western, P. S., Ralli, R., Wakeling, S. I., Lo, C. Y.-W., van den Bergen, J. A., Miles, D. C., & Sinclair, A. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020736 · Cited by 35
Iwata, E., Mikami, K., Manbo, J., Moriya‐Ito, K., & Sasaki, H. (2012) · ZOOLOGICAL SCIENCE · doi:10.2108/zsj.29.849 · Cited by 35
Piprek, R. P., Damulewicz, M., Kloc, M., & Kubiak, J. Z. (2018) · Differentiation · doi:10.1016/j.diff.2018.02.004 · Cited by 33
Nakamura, M., Specker, J. L., & Nagahama, Y. (1993) · Cell and Tissue Research · doi:10.1007/bf00323568 · Cited by 32
Self-citationThe Mechanism of Germline Sex Determination in Vertebrates
Nishimura, T., & Tanaka, M. (2016) · Biology of Reproduction · doi:10.1095/biolreprod.115.138271 · Cited by 31
Gonadal and Endocrine Analysis of a Gynandromorphic Chicken
Morris, K. R., Hirst, C. E., Major, A. T., Ezaz, T., Ford, M. E., Bibby, S., Doran, T. J., & Smith, C. A. (2018) · Endocrinology · doi:10.1210/en.2018-00553 · Cited by 31
Gonadal Differentiation in Reptiles Exhibiting Environmental Sex Determination
Kohno, S., Parrott, B. B., Yatsu, R., Miyagawa, S., Moore, B. C., Iguchi, T., & Guillette, L. J. (2014) · Sexual Development · doi:10.1159/000358892 · Cited by 30
Molecular evolution of two distinct dmrt1 promoters for germ and somatic cells in vertebrate gonads
Mawaribuchi, S., Musashijima, M., Wada, M., Izutsu, Y., Kurakata, E., Park, M. K., Takamatsu, N., & Ito, M. (2016) · Molecular Biology and Evolution · doi:10.1093/molbev/msw273 · Cited by 30
Nakamoto, M., Fukasawa, M., Orii, S., Shimamori, K., Maeda, T., Suzuki, A. S., Matsuda, M., Kobayashi, T., Nagahama, Y., & Shibata, N. (2010) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2010.01178.x · Cited by 28
Self-citationSteroids, aromatase and sex differentiation of the newt Pleurodeles waltl
Kuntz, S., Chardard, D., Chesnel, A., et al. (2003) · Cytogenetic and Genome Research · doi:10.1159/000074350 · Cited by 28
The Curious World of Gonadal Development in Mammals
Koopman, P. A. (2016) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2015.12.009 · Cited by 26
Epigenetics of sex determination in mammals
Tachibana, M. (2015) · Reproductive Medicine and Biology · doi:10.1007/s12522-015-0223-7 · Cited by 25
Luo, D., Liu, Y., Chen, J., Xia, X.-Q., Cao, M., Cheng, B., Wang, X., Gong, W., Qiu, C., Zhang, Y., et al. (2015) · Scientific Reports · doi:10.1038/srep14057 · Cited by 25
Participation of androgen and its receptor in sex determination of an amphibian species
Oike, A., Kodama, M., Yasumasu, S., Yamamoto, T., Nakamura, Y. T., Ito, E., & Nakamura, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178067 · Cited by 25
Self-citationA role for estrogen in somatic cell fate of the mammalian gonad
Pask, A. J. (2011) · Chromosome Research · doi:10.1007/s10577-011-9260-1 · Cited by 24
Sexual Development of the Urodele Amphibian Pleurodeles waltl
Dumond, H., Kuntz, S., Chesnel, A., Ko, C.-I., Wallacides, A., Chardard, D., & Flament, S. (2008) · Sexual Development · doi:10.1159/000129695 · Cited by 23
Hinfray, N., Sohm, F., Caulier, M., Chadili, E., Piccini, B., Torchy, C., Porcher, J., Guiguen, Y., & Brion, F. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.06.014 · Cited by 23
Chen, Y., Hong, W., Wang, Q., & Chen, S. X. (2015) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2015.02.018 · Cited by 22
R‐spondin1—discovery of the long‐missing, mammalian female‐determining gene?
Wilhelm, D. (2007) · BioEssays · doi:10.1002/bies.20553 · Cited by 22
The varied ways of being male and female
Schärer, L. (2016) · Molecular Reproduction and Development · doi:10.1002/mrd.22775 · Cited by 22
Wang, Q., Mank, J. E., Li, J., Yang, N., & Qu, L. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evx031 · Cited by 22
Jeong, Y.-H., Lu, H., Park, C., Li, M., Luo, H., Kim, J. J., Liu, S. M., Ko, K. H., Huang, S., Hwang, I. S., et al. (2016) · Scientific Reports · doi:10.1038/srep31088 · Cited by 21
Characterization of the Xp21–23 region in the wood lemming, a region involved in XY sex reversal
Liu, W., Nordqvist, K., Lau, Y. C., & Fredga, K. (2001) · Journal of Experimental Zoology · doi:10.1002/jez.1105 · Cited by 15
Sex determination by multiple sex chromosomes in Xenopus tropicalis
Schartl, M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1513518112 · Cited by 13
Molecular characterization of the Bidder's organ in the cane toad (Bufo marinus)
Abramyan, J., Wilhelm, D., & Koopman, P. A. (2010) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21357 · Cited by 7
Wada, M., Fujitani, K., Tamura, K., Mawaribuchi, S., Kamata, Y., Takamatsu, N., & Ito, M. (2017) · ZOOLOGICAL SCIENCE · doi:10.2108/zs160185 · Cited by 6
Integrative and comparative reproductive biology: From alligators to xenobiotics
McCoy, K. A., Roark, A. M., Boggs, A. S. P., Bowden, J. A., Cruze, L., Edwards, T. M., Hamlin, H. J., Cantu, T. M., McCoy, J. A., McNabb, N. A., et al. (2016) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2016.03.026 · Cited by 5
Metadata
- Authors
- Nagahama, Y., Chakraborty, T., Paul-Prasanth, B., Ohta, K., & Nakamura, M.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2021-07-01
- Volume
- 101
- Issue
- 3
- Pages
- 1237-1308
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W3100361446
- Cited by
- 346
- References
- 453
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
