The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-γActivation
Open accessAbstract
Curcumin, the phytochemical component in turmeric, is used as a dietary spice and a topical ointment for the treatment of inflammation in India for centuries. Curcumin (diferuloylmethane) is relatively insoluble in water, but dissolves in acetone, dimethylsulphoxide, and ethanol. Commercial grade curcumin contains 10–20% curcuminoids, desmethoxycurcumin, and bisdesmethoxycurcumin and they are as effective as pure curcumin. Based on a number of clinical studies in carcinogenesis, a daily oral dose of 3.6 g curcumin has been efficacious for colorectal cancer and advocates its advancement into Phase II clinical studies. In addition to the anticancer effects, curcumin has been effective against a variety of disease conditions in both in vitro and in vivo preclinical studies. The present review highlights the importance of curcumin as an anti-inflammatory agent and suggests that the beneficial effect of curcumin is mediated by the upregulation of peroxisome proliferator-activated receptor-γ(PPAR-γ) activation.
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Cites
Angiogenesis in cancer, vascular, rheumatoid and other disease
Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525
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Inflammation and Alzheimer’s disease
Lee, Y.-J., Han, S. B., Nam, S.-Y., Oh, K.-W., & Hong, J. T. (2010) · Archives of Pharmacal Research · doi:10.1007/s12272-010-1006-7 · Cited by 396
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Santini, A., Tenore, G. C., & Novellino, E. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.09.003 · Cited by 293
Kim, Y., Kim, C.-S., Joe, Y., Chung, H. T., Ha, T. Y., & Yu, R. (2018) · Journal of Medicinal Food · doi:10.1089/jmf.2017.4108 · Cited by 69
Haller, O. J., Semendric, I., George, R. P., Collins-Praino, L. E., & Whittaker, A. L. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105120 · Cited by 13
Metadata
- Authors
- Jacob, A., Wu, R., Zhou, M., & Wang, P.
- Venue
- PPAR Research
- Publisher
- Wiley
- Published
- 2007
- Volume
- 2007
- Pages
- 1-5
- ISSN
- 1687-4757 (ISSN-L)
- 1687-4765
- OpenAlex
- W2015312906
- Cited by
- 228
- References
- 2
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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