Peroxisome proliferator-activated receptor and age-related macular degeneration
Open accessAbstract
Age-related macular degeneration (AMD) is the leading cause of new blindness in the western world and is becoming more of a socio-medical problem as the proportion of the aged population increases. There are multiple efforts underway to better understand this disease process. AMD involves the abnormal retinal pigment epithelium (RPE), drusen formation, photoreceptor atrophy, and choroidal neovascularization. Peroxisome proliferator-activated receptors (PPARs) play an important role in lipid degeneration, immune regulation, regulation of reactive oxygen species (ROSs), as well as regulation of vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), and docosahexaenoic acid (DHA). These molecules have all been implicated in the pathogenesis of AMD. In addition, PPAR gamma is expressed in RPE, an essential cell in photoreceptor regeneration and vision maintenance. This review summarizes the interactions between PPAR, AMD-related molecules, and AMD-related disease processes.
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The Ccl2−/−/Cx3cr1−/− mouse model demonstrates many AMD features: small drusenoid deposits, RPE and Bruch's membrane degenerations, photoreceptor atrophy, CNV, and simulation of the immunologic and pathologic environments found in AMD patients.
“The Ccl2−/−/Cx3cr1−/− mouse model demonstrates many AMD features: small drusenoid deposits, RPE and Bruch’s membrane degenerations, photoreceptor atrophy, CNV, and simulation of the immunologic and pathologic environments found in AMD patients (Herzlich et al., 2008; Ross et al., 2008; Ding et al., 2009).”
From Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD) (2010) · cites this paper as Herzlich et al., 2008
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References 120 · Cited by 43
Research works printed but not linked: 2
- [91]Hageman GS Anderson DH Johnson LV A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration Proceedings of the National Academy of Sciences of the United States of America 2005 102 20 7227 7232 15870199 PMC1088171
- [93]Hageman GS Luthert PJ Victor Chong NH Johnson LV Anderson DH Mullins RF An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration Progress in Retinal and Eye Research 2001 20 6 705 732 11587915
- Authors
- Herzlich, A. A., Tuo, J., & Chan, C.-C.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Chan, Chi-Chao
- Venue
- PPAR Research
- Publisher
- Wiley
- Published
- 2008-01
- Volume
- 2008
- Issue
- 1
- Pages
- 389507-389507
- ISSN
- 1687-4757 (ISSN-L)
- 1687-4765
- PMC
- PMC2234091
- OpenAlex
- W2034826672
- Cited by
- 43
- References
- 120
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 1 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 5
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PPAR Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- age-related macular degeneration, peroxisome proliferator-activated receptors, PPARγ, retinal pigment epithelium, drusen formation, photoreceptor atrophy, choroidal neovascularization, reactive oxygen species, vascular endothelial growth factor, MMP-9, docosahexaenoic acid, immune regulation, photoreceptor regeneration
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