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Cited by 77Pituitary Gland Disorders and TreatmentsSleep and Wakefulness ResearchCircadian rhythm and melatonin

Increased Daytime Sleepiness in Patients with Childhood Craniopharyngioma and Hypothalamic Tumor Involvement: Review of the Literature and Perspectives

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Müller, Hermann L.·2010·International Journal of Endocrinology
DOI 10.1155/2010/519607PMC PMC3017941
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Abstract

Childhood craniopharyngiomas are rare embryogenic malformations of the sellar region, presumably derived from Rathke cleft epithelium. The overall survival rates after neurosurgical intervention and/or irradiation are high (92%). However, the quality of survival is frequently impaired due to endocrine deficiencies, sleep disturbances, daytime sleepiness, and severe obesity caused by hypothalamic lesions. Based on self-assessment using nutritional diaries, caloric intake was similar in patients and BMI-matched controls. Analyses of physical activity by accelerometric measurements showed a markedly lower level of physical activity. Significant daytime sleepiness and disturbances of circadian rhythms have been demonstrated in obese childhood craniopharyngioma patients. Daytime sleepiness and obesity in these patients were both correlated with low nocturnal and early morning melatonin levels. Polysomnographic studies in patients with severe daytime sleepiness revealed sleeping patterns typical for secondary narcolepsy. Reports on a beneficial effect of treatment with central stimulating agents supported the hypothesis that secondary narcolepsy should be considered as a rare cause for severe daytime sleepiness in patients with childhood craniopharyngioma.

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  • Fatigue in individuals with hypothalamic syndrome could potentially be related to disordered signaling from GABAergic neurons in the suprachiasmatic, ventrolateral, and preoptic nuclei.

    “Commonly reported fatigue (72, 73) could potentially be related to disordered signaling from γ-aminobutyric acid (GABA)-ergic neurons in the suprachiasmatic, ventrolateral, and preoptic nuclei (74, 75).”

    From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [73]

    The paper’s Abstract links hypothalamic injury, including possible suprachiasmatic nucleus dysfunction, to increased daytime sleepiness in patients with childhood craniopharyngioma. It does not attribute that symptom to disordered GABAergic signaling in the suprachiasmatic, ventrolateral, and preoptic nuclei; its discussion instead focuses on melatonin and orexin. (LLM, conf=0.82)

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References 57 · Cited by 77

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Authors
Müller, H. L.
Affiliations
Department of Paediatrics and Paediatric Hematology and Oncology, Klinikum Oldenburg, Rahel-Straus-Straße 10, 26133 Oldenburg, Germany
Venue
International Journal of Endocrinology
Publisher
Wiley
Published
2010
Volume
2010
Pages
1-7
ISSN
  • 1687-8337 (ISSN-L)
  • 1687-8345
DOI
10.1155/2010/519607
PMC
PMC3017941
OpenAlex
W2083867031
Cited by
77
References
57
Citations by year
2026: 4 · 2025: 7 · 2024: 4 · 2023: 6 · 2022: 9 · 2021: 5 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 8 · 2012: 4
FWCI
1.21
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Endocrinology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Deutsche Kinderkrebsstiftung
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
childhood craniopharyngioma, hypothalamic tumors, daytime sleepiness, hypothalamic obesity, circadian rhythm disruption, melatonin, physical activity, sleep-disordered breathing, endocrine insufficiency

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