Influenza and Bacterial Pathogen Coinfections in the 20th Century
Open accessAbstract
To help understand the potential impact of bacterial coinfection during pandemic influenza periods, we undertook a far-reaching review of the existing literature to gain insights into the interaction of influenza and bacterial pathogens. Reports published between 1950 and 2006 were identified from scientific citation databases using standardized search terms. Study outcomes related to coinfection were subjected to a pooled analysis. Coinfection with influenza and bacterial pathogens occurred more frequently in pandemic compared with seasonal influenza periods. The most common bacterial coinfections with influenza virus were due to S. pneumoniae,H. influenzae,Staphylococcus spp., and Streptococcus spp. Of these,S. pneumoniae was the most common cause of bacterial coinfection with influenza and accounted for 40.8% and 16.6% of bacterial coinfections during pandemic and seasonal periods, respectively. These results suggest that bacterial pathogens will play a key role in many countries, as the H1N1(A) influenza pandemic moves forward. Given the role of bacterial coinfections during influenza epidemics and pandemics, the conduct of well-designed field evaluations of public health measures to reduce the burden of these common bacterial pathogens and influenza in at-risk populations is warranted.
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The frequency of overall bacterial coinfection in influenza patients is still poorly characterized.
“While prior studies have examined the frequency of select bacterial species in influenza cases,13, 14 particularly the presence of methicillin‐resistant S. aureus (MRSA),15, 16, 17, 18 the frequency of overall coinfection in influenza patients is still poorly characterized.”
From The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis. (2016) · cites this paper as [14]
Certain bacterial pathogens, such as Streptococcus pneumoniae, are commonly isolated from patients with secondary bacterial infections.
“Certain bacterial pathogens have been commonly isolated from patients with secondary bacterial infections, such as Streptococcus pneumoniae, (4, 11, 12).”
From Depletion of alveolar macrophages during influenza infection facilitates bacterial superinfections (2013) · cites this paper as [11]
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References 15 · Cited by 37
Research works printed but not linked: 1
- [8]Glasziou P Irwig I Bain C Colditz G Frequency and Rate. Systematic Reviews Inhealth Care: A Practical Guide 2001 2nd edition Cambridge, UK Cambridge University Press
- Authors
- Wang, X.-Y., Kilgore, P. E., Lim, K. A., Wang, S.-M., Lee, J., Deng, W., Mo, M.-Q., Nyambat, B., Ma, J.-C., Favorov, M. O., & Clemens, J. D.
- Affiliations
- Shanghai Medical College of Fudan University (CN)
- International Vaccine Institute (KR)
- International Vaccine Institute, Seoul 151-818, Republic of Korea
- Fudan University (CN)
- Corresponding author
- Wang, Xuan-Yi
- Venue
- Interdisciplinary Perspectives on Infectious Diseases
- Publisher
- Wiley
- Published
- 2011
- Volume
- 2011
- Pages
- 1-6
- ISSN
- 1687-708X (ISSN-L)
- 1687-7098
- PMC
- PMC3124839
- OpenAlex
- W2090045305
- Cited by
- 37
- References
- 15
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 5
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Interdisciplinary Perspectives on Infectious Diseases (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Government of Kuwait
- Governments of Sweden
- Government of the Republic of Korea
- Merck
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- influenza, bacterial co-infection, pandemic influenza, seasonal influenza, Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus, Streptococcus, H1N1 influenza pandemic, public health measures
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