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Cited by 79Sperm and Testicular FunctionMale Reproductive Health StudiesHormonal and reproductive studies

Does Varicocelectomy Improve Gonadal Function in Men with Hypogonadism and Infertility? Analysis of a Prospective Study

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Sathya Srini, Vasan, Belur Veerachari, Srinivas·2011·International Journal of Endocrinology
DOI 10.1155/2011/916380PMC PMC3235454
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Abstract

Varicocele in infertile males is associated with Leydig cell dysfunction and hypogonadism. The effect of varicocelectomy on serum testosterone level is not yet established. We analysed 200 heterosexual infertile men diagnosed to have clinical varicocele they were divided into two groups: group 1 (100 men) had microsurgical varicocelectomy, and group 2 (100 patients) underwent assisted reproduction procedures. All participants had semen analysis, serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, and total testosterone (TT), measured both at recruitment time and 6 months later. In group 1, the mean TT level increased significantly after varicocelectomy (1.644±0.029to2.461±0.0198 ng/dL,P<0.0001) and testicular size correlated with the mean change in TT (P=0.001). No similar change was found in group 2. Out of the 100 patients in group 1, 78 had postoperative normalization of TT unlike only 16 men in group 2.

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  • In 100 men with primary or secondary infertility, average testosterone 177 ng/dL and clinical varicocele who underwent microscopic varicocelectomy, testosterone rose significantly to a mean of 301 ng/dL.

    “Sathya et al. assessed 100 men with primary or secondary infertility, with average testosterone of 177 ng/dL and clinical varicocele, who underwent microscopic varicocelectomy. Following varicocelectomy, testosterone rose significantly to a mean of 301 ng/dL (P<0.001) (24).”

    From Non-testosterone management of male hypogonadism: an examination of the existing literature (2020) · cites this paper as [24]

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Cited by

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Authors
Sathya Srini, V., & Belur Veerachari, S.
Affiliations
Department of Andrology, Ankur Health Care Private Limited, No. 55, 20th Main, 1st Block, Rajajinagar, Bengaluru 560010, India
Venue
International Journal of Endocrinology
Publisher
Hindawi Limited
Published
2011
Volume
2011
Pages
1-6
ISSN
  • 1687-8337 (ISSN-L)
  • 1687-8345
DOI
10.1155/2011/916380
PMC
PMC3235454
OpenAlex
W2142613462
Cited by
79
References
1
Citations by year
2026: 2 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 8 · 2016: 6 · 2015: 4 · 2014: 9 · 2013: 6 · 2012: 5
FWCI
7.17
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Endocrinology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Ankur RITS
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Health Professions › General Health Professions › Male Reproductive Health Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
varicocelectomy, varicocele, male infertility, hypogonadism, gonadal function, testosterone, Leydig cell dysfunction, microsurgical varicocelectomy, assisted reproduction, testicular volume, luteinizing hormone, follicle-stimulating hormone

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