Theranostic implications of nanotechnology in multiple sclerosis: a future perspective.
Open accessAbstract
Multiple Sclerosis is a multifactorial disease with several pathogenic mechanisms and pathways. Successful MS management and medical care requires early accurate diagnosis along with specific treatment protocols based upon multifunctional nanotechnology approach. This paper highlights advances in nanotechnology that have enabled the clinician to target the brain and CNS in patient with multiple sclerosis with nanoparticles having therapeutic and imaging components. The multipartite theranostic (thera(py) + (diag)nostics) approach puts forth strong implications for medical care and cure in MS. The current nanotheranostics utilize tamed drug vehicles and contain cargo, targeting ligands, and imaging labels for delivery to specific tissues, cells, or subcellular components. A brief overview of nonsurgical nanorepair advances as future perspective is also described. Considering the potential inflammatory triggers in MS pathogenesis, a multifunctional nanotechnology approach will be needed for the prognosis.
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The theranostic approach has potential applications in medical care and cure of multiple sclerosis.
“The theranostic approach has been found to possess potential applications in the field of medical care and cure of MS”
From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Singh et al., 2012
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References 115 · Cited by 58
Research works printed but not linked: 1
- [31]D’Aversa TG Mylin basic protein induces inflamattory mediatirs from primary human endothelial cells and blood brain barrier disruption: implications of the multiple sclerosis Neuropathology and Applied Neurobiology. In press
- Authors
- Singh, A. V., Khare, M., Gade, W. N., & Zamboni, P.
- Affiliations
- Rensselaer Polytechnic Institute (US)
- Department of Applied Sciences, Maharashtra Academy of Engineering, Alandi (D), Pune 412 105, India
- Savitribai Phule Pune University (IN)
- University of Ferrara (IT)
- Corresponding author
- Singh, Ajay Vikram
- Venue
- Autoimmune Diseases
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-12
- ISSN
- 2090-0422 (ISSN-L)
- 2090-0430
- PMC
- PMC3546454
- OpenAlex
- W2032870077
- Cited by
- 58
- References
- 115
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 1 · 2020: 3 · 2019: 5 · 2018: 7 · 2017: 9 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 4
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Autoimmune Diseases (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- multiple sclerosis, theranostics, nanotechnology, nanoparticles, drug delivery, brain targeting, central nervous system, targeting ligands, inflammation, diagnosis
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