Obesity Differentially Affects Phenotypes of Polycystic Ovary Syndrome
Open accessAbstract
Obesity or overweight affect most of patients with polycystic ovary syndrome (PCOS). Phenotypes are the clinical characteristics produced by the interaction of heredity and environment in a disease or syndrome. Phenotypes of PCOS have been described on the presence of clinical hyperandrogenism, oligoovulation and polycystic ovaries. The insulin resistance is present in the majority of patients with obesity and/or PCOS and it is more frequent and of greater magnitude in obese than in non obese PCOS patients. Levels of sexual hormone binding globulin are decreased, and levels of free androgens are increased in obese PCOS patients. Weight loss treatment is important for overweight or obese PCOS patients, but not necessary for normal weight PCOS patients, who only need to avoid increasing their body weight. Obesity decreases or delays several infertility treatments. The differences in the hormonal and metabolic profile, as well as the different focus and response to treatment between obese and non obese PCOS patients suggest that obesity has to be considered as a characteristic for classification of PCOS phenotypes.
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PCOS increases the risk of type 2 diabetes and obesity in women, thus in utero androgen exposure may both directly and indirectly have an impact on adiposity in later life.
“PCOS increases the risk of type 2 diabetes and obesity in women, thus in utero androgen exposure may both directly and indirectly have an impact on adiposity in later life [129, 130].”
From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [129]
Section 6.2 identifies PCOS as a risk factor for type 2 diabetes, and the Introduction and Section 4 associate PCOS with overweight or obesity. They do not establish that PCOS increases the risk of obesity. Section 12 says information about hormonal and metabolic factors during intrauterine life is scarce; it does not support the proposed direct or indirect effect of in utero androgen exposure on later-life adiposity. (LLM, conf=0.86)
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References 64 · Cited by 86
Research works printed but not linked: 3
- [1]Lunde O Magnus P Sandvik L Hoglo S Familial clustering in the polycystic ovarian syndrome Gynecologic and Obstetric Investigation 1989 28 1 23 30 2-s2.0-0024392667 2777131
- [10]Zawadzki JK Dunaif A Dunaif A Givens JR Haseltine FP Merriam GR Diagnostic criteria for polycystic ovary syndrome: towards a rational approach Polycystic Ovary Syndrome 1992 chapter 32 Boston, Mass, USA Blackwell 377 384
- [17]Moran C Arriaga M Rodriguez G Moran S Mukherjee S Obesity in polycystic ovary syndrome Polycystic Ovary Syndrome 2012 chapter 5 Rijeka, Croatia In Tech 77 92
- Authors
- Moran, C., Arriaga, M., Rodriguez, G., & Moran, S.
- Affiliations
- Direction of Health Research and Training, Medical Unit of High Specialty, Gynecology and Obstetrics Hospital No. 4 Luis Castelazo Ayala, Mexican Institute of Social Security, Mexico City, DF 01090, Mexico
- Mexican Social Security Institute (MX)
- Health Research Council, Mexican Institute of Social Security, Mexico City, DF 06725, Mexico
- ORCID
- Moran, Segundo
- Venue
- International Journal of Endocrinology
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-7
- ISSN
- 1687-8337 (ISSN-L)
- 1687-8345
- PMC
- PMC3399368
- OpenAlex
- W2030226938
- Cited by
- 86
- References
- 64
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 8 · 2021: 10 · 2020: 6 · 2019: 4 · 2018: 7 · 2017: 1 · 2016: 5 · 2015: 8 · 2014: 4 · 2013: 10 · 2012: 2
- FWCI
- 8.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Keywords
- polycystic ovary syndrome, obesity, PCOS phenotypes, insulin resistance, hyperandrogenism, oligoovulation, weight loss, infertility treatment, body weight
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