Intramuscular adipose tissue, sarcopenia, and mobility function in older individuals
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Objective . Intramuscular adipose tissue (IMAT) and sarcopenia may adversely impact mobility function and physical activity. This study determined the association of locomotor muscle structure and function with mobility function in older adults. Method . 109 older adults with a variety of comorbid disease conditions were examined for thigh muscle composition via MRI, knee extensor strength via isometric dynamometry, and mobility function. The contribution of strength, quadriceps lean tissue, and IMAT to explaining the variability in mobility function was examined using multivariate linear regression models. Results . The predictors as a group contributed 27–45% of the variance in all outcome measures; however, IMAT contributed between 8–15% of the variance in all four mobility variables, while lean explained only 5% variance in only one mobility measure. Conclusions . Thigh IMAT, a newly identified muscle impairment appears to be a potent muscle variable related to the ability of older adults to move about in their community.
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Obesity and changes in fat mass introduce artifacts that may compromise DXA accuracy and precision.
“Limitations due to DXA technology include the fact that obesity itself and changes in fat mass introduce artifacts that may compromise accuracy and precision.30-33”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [31]
Multiple studies have found a similar relationship between increased myosteatosis in the lower extremities and decreased mobility.
“Multiple studies have found a similar relationship between increased myosteatosis in the lower extremities and decreased mobility (Tuttle et al., 2011, 2012; Marcus et al., 2012).”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Marcus et al., 2012
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References 28 · Cited by 296
Research works printed but not linked: 1
- [27]Marcus RL Kidde J Dibble L Addison O LaStayo PC Intramuscular fat in older adults and the impact of resistance training The Journal of Nutrition, Health and Aging 2008 12 7
- Authors
- Marcus, R. L., Addison, O., Dibble, L. E., Foreman, K. B., Morrell, G., & LaStayo, P.
- Affiliations
- University of Utah (US)
- Corresponding author
- Marcus, Robin L.
- Venue
- Journal of Aging Research
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-6
- ISSN
- 2090-2204 (ISSN-L)
- 2090-2212
- PMC
- PMC3303569
- OpenAlex
- W1991681137
- Cited by
- 296
- References
- 28
- Citations by year
- 2026: 16 · 2025: 20 · 2024: 20 · 2023: 18 · 2022: 27 · 2021: 30 · 2020: 23 · 2019: 23 · 2018: 29 · 2017: 21 · 2016: 18 · 2015: 21 · 2014: 16 · 2013: 11 · 2012: 3
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Aging Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- intramuscular fat, sarcopenia, mobility function, older adults, quadriceps strength, muscle structure, physical activity, comorbid diseases
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