The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Effects of Thymol and Carvacrol, Constituents of Thymus vulgaris L. Essential Oil, on the Inflammatory Response
Open accessAbstract
Thyme (Thymus vulgaris L., Lamiaceae) is an aromatic and medicinal plant that has been used in folk medicine, phytopharmaceutical preparations, food preservatives, and as an aromatic ingredient. The effect of Thymus vulgaris essential oil (TEO) and its isolated constituents thymol and cavacrol (CVL) were studied in the following experimental models: ear edema, carrageenan-induced pleurisy, and chemotaxis in vitro. In the pleurisy model, TEO, CVL, and thymol significantly inhibited inflammatory edema. However, only TEO and CVL inhibited leukocyte migration. In the in vitro chemotaxis experiment, CVL inhibited leukocyte migration, whereas thymol exerted a potent chemoattractant effect. In the ear edema model, CVL (10 mg/ear), applied topically, reduced edema formation, exerting a topical anti-inflammatory effect. Thymol did not reduce edema formation but rather presented an irritative response, probably dependent on histamine and prostanoid release. Our data suggest that the antiinflammatory effects of TEO and CVL are attributable to the inhibition of inflammatory edema and leukocyte migration.
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Cites
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Cited by
Conde-Díaz, A., Santana-Mayor, Á., Herrera-Herrera, A. V., Socas-Rodríguez, B., & Rodríguez-Delgado, M. Á. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.139480 · Cited by 23
Metadata
- Authors
- Fachini-Queiroz, F. C., Kummer, R., Estevão-Silva, C. F., Carvalho, M. D. D. B., Cunha, J. M., Grespan, R., Bersani-Amado, C. A., & Cuman, R. K. N.
- Venue
- Evidence-Based Complementary and Alternative Medicine
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-10
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- OpenAlex
- W2162341513
- Cited by
- 304
- References
- 36
- FWCI
- 19.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Fachini-Queiroz, F. C., Kummer, R., Estevão-Silva, C. F., Carvalho, M. D. D. B., Cunha, J. M., Grespan, R., Bersani-Amado, C. A., & Cuman, R. K. N. (2012). Effects of Thymol and Carvacrol, Constituents of Thymus vulgaris L. Essential Oil, on the Inflammatory Response. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2012/657026
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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