Ocular manifestations of Alzheimer's disease in animal models
Open accessAbstract
Alzheimer's disease (AD) is the most common form of dementia, and the pathological changes of senile plaques (SPs) and neurofibrillary tangles (NFTs) in AD brains are well described. Clinically, a diagnosis remains a postmortem one, hampering both accurate and early diagnosis as well as research into potential new treatments. Visual deficits have long been noted in AD patients, and it is becoming increasingly apparent that histopathological changes already noted in the brain also occur in an extension of the brain; the retina. Due to the optically transparent nature of the eye, it is possible to image the retina at a cellular level noninvasively and thus potentially allow an earlier diagnosis as well as a way of monitoring progression and treatment effects. Transgenic animal models expressing amyloid precursor protein (APP) presenilin (PS) and tau mutations have been used successfully to recapitulate the pathological findings of AD in the brain. This paper will cover the ocular abnormalities that have been detected in these transgenic AD animal models.
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Significant upregulation of inflammation (astroglial and microglial activation) is found in retinas of AD mouse models in relation to Aβ plaques.
“A significant upregulation of inflammation (evidenced by astroglial and microglial activation) has been found in the retinas of AD mouse models in relation to Aβ plaques (Parnell et al., 2012).”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Parnell et al., 2012
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References 138 · Cited by 56
- Authors
- Parnell, M., Guo, L., Abdi, M., & Cordeiro, M. F.
- Affiliations
- Epsom and St Helier University Hospitals NHS Trust (GB)
- University College London (GB)
- St George’s University Hospitals NHS Foundation Trust (GB)
- Imperial College Healthcare NHS Trust (GB)
- Corresponding author
- Cordeiro, M. Francesca
- Venue
- International Journal of Alzheimer s Disease
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-13
- ISSN
- 2090-0252 (ISSN-L)
- 2090-8024
- PMC
- PMC3362039
- OpenAlex
- W2030698780
- Cited by
- 56
- References
- 138
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 8 · 2015: 6 · 2014: 7 · 2013: 5
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- International Journal of Alzheimer s Disease (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- Alzheimer's disease, ocular manifestations, retinal changes, transgenic animal models, amyloid precursor protein, presenilin, tau mutations, amyloid plaques, neurofibrillary tangles, early diagnosis, retinal imaging, non-invasive imaging
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