Redox Status Is Critical for Stemness in Skin Equivalents
Open accessAbstract
The skin is constantly exposed to environmental oxidative stress. Skin equivalent (SE) models are three-dimensional systems in which cell-cell or cell-matrix interactions can be investigated. In this study, the effects of vitamin C or plant extracts with high antioxidant activities were tested. There was no significant difference in the epidermal thickness, but the basal cells became cuboidal when vitamin C or plant extracts were supplemented. Furthermore, immunohistochemical staining showed linear and intense staining of α 6 and β 1 integrin along the basement membrane in vitamin C or plant extract treated models. The p63 and PCNA were also stained. Results showed that the number of p63 and PCNA positive cells was higher in the vitamin C or plant extract treated models than in the control SEs. Although the relationship between oxidative stress and stem cells is not known, our results suggest that redox status affects the stemness and the proliferative potential of epidermal basal cells by modulating microenvironment to epidermal basal stem cells.
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Redox status is essential for stemness in skin equivalents.
“Choi et al. suggested that redox status is essential for stemness in skin equivalents”
From Ultraviolet Radiation‐Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging (2016) · cites this paper as [167]
Vitamin C, plant extracts (G. lucidum and R. sachalinensis), and a novel tripeptide ACQ having high antioxidant activities promote stemness and the proliferative capacity of epidermal basal cells by improving the microenvironment through regulation of integrins.
“Choi et al. suggested that redox status is essential for stemness in skin equivalents and demonstrated that vitamin C, plant extracts (G. lucidum and R. sachalinensis), and a novel tripeptide “ACQ: alanine-cysteine-glutamine” having high antioxidant activities promoted stemness and the proliferative capacity of epidermal basal cells by improving microenvironment through regulation of integrins,”
From Ultraviolet Radiation‐Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging (2016) · cites this paper as [167]
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References 27 · Cited by 8
- Authors
- Choi, H.-R., Kang, Y.-A., Shin, J.-W., Na, J.-I., Huh, C.-H., & Park, K.-C.
- Affiliations
- Seoul National University (KR)
- Department of Dermatology, Bundang Seoul National University Hospital, Seoul National University College of Medicine, 166 Gumi-ro, Bundang-gu, Seongnam-si 463-707, Republic of Korea
- Corresponding author
- Park, Kyoung-Chan
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Hindawi Limited
- Published
- 2012
- Volume
- 2012
- Pages
- 1-7
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC3437688
- OpenAlex
- W2005911144
- Cited by
- 8
- References
- 27
- Citations by year
- 2024: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 2
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- skin equivalents, redox state, oxidative stress, stemness, epidermal basal cells, vitamin C, plant extracts, antioxidants, p63, PCNA, integrins, basement membrane, epidermal stem cells, cell proliferation
- MeSH terms
- Antioxidants, Ascorbic Acid, Cells, Cultured, Fibroblasts, Humans, Oxidation-Reduction, Plant Extracts, Skin, Transcription Factors, Keratinocytes, Proliferating Cell Nuclear Antigen, Cell Culture Techniques, Integrin beta1, Tumor Suppressor Proteins, Integrin alpha6, Cell Proliferation
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