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Cited by 165Impact of Technology on AdolescentsNeurotransmitter Receptor Influence on BehaviorGambling Behavior and Treatments

Reduced Striatal Dopamine Transporters in People with Internet Addiction Disorder

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Hou, Haifeng, Jia, Shaowe, Hu, Shu, Fan, Rong, Sun, Wen, Sun, Taotao, Zhang, Hong·2012·Journal of Biomedicine and Biotechnology
DOI 10.1155/2012/854524PMC PMC3312312
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Abstract

In recent years, internet addiction disorder (IAD) has become more prevalent worldwide and the recognition of its devastating impact on the users and society has rapidly increased. However, the neurobiological mechanism of IAD has not bee fully expressed. The present study was designed to determine if the striatal dopamine transporter (DAT) levels measured by T 99 m c -TRODAT-1 single photon emission computed tomography (SPECT) brain scans were altered in individuals with IAD. SPECT brain scans were acquired on 5 male IAD subjects and 9 healthy age-matched controls. The volume ( V ) and weight ( W ) of bilateral corpus striatum as well as the T 99 m c -TRODAT-1 uptake ratio of corpus striatum/the whole brain (Ra) were calculated using mathematical models. It was displayed that DAT expression level of striatum was significantly decreased and the V , W , and Ra were greatly reduced in the individuals with IAD compared to controls. Taken together, these results suggest that IAD may cause serious damages to the brain and the neuroimaging findings further illustrate IAD is associated with dysfunctions in the dopaminergic brain systems. Our findings also support the claim that IAD may share similar neurobiological abnormalities with other addictive disorders.

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  • The same molecular pathways, such as dopaminergic pathways, that operate in substance addictions are implicated in internet addiction.

    “Third, the same molecular pathways (e.g., dopaminergic) that operate in substance addictions are implicated in internet addiction (Hou, Jia, Hu, Fan, Sun, Sun, & Zhang, 2012; Shaffer et al., 2004; Tian et al., 2014).”

    From Ethics of the Attention Economy: The Problem of Social Media Addiction (2021) · cites this paper as Hou et al., 2012

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References 35 · Cited by 165

Research works printed but not linked: 29

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Authors
Hou, H., Jia, S., Hu, S., Fan, R., Sun, W., Sun, T., & Zhang, H.
Affiliations
  • Second Affiliated Hospital of Zhejiang University (CN)
  • Peking University Shenzhen Hospital (CN)
Corresponding author
Zhang, Hong
ORCID
Venue
Journal of Biomedicine and Biotechnology
Publisher
Wiley
Published
2012
Volume
2012
Pages
1-5
ISSN
  • 1110-7243 (ISSN-L)
  • 1110-7251
DOI
10.1155/2012/854524
PMC
PMC3312312
OpenAlex
W1989789686
Cited by
165
References
35
Citations by year
2026: 7 · 2025: 7 · 2024: 11 · 2023: 13 · 2022: 13 · 2021: 12 · 2020: 15 · 2019: 10 · 2018: 12 · 2017: 11 · 2016: 10 · 2015: 18 · 2014: 15 · 2013: 9 · 2012: 2
FWCI
46.42
Type
journal article
Language
en
Open access
Licence
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Natural Science Foundation of China (81101023, 81170306, 81173468, Z2110230, 2010ZA075, 2011ZDA013, 2011CB504400, 2012BAI13B06)
  • Natural Science Foundation of Zhejiang Province (81101023, 81170306, 81173468, Z2110230, 2010ZA075, 2011ZDA013, 2011CB504400, 2012BAI13B06)
  • Health Bureau of Zhejiang Province (81101023, 81170306, 81173468, Z2110230, 2010ZA075, 2011ZDA013, 2011CB504400, 2012BAI13B06)
  • Ministry of Science and Technology of the People’s Republic of China (81101023, 81170306, 81173468, Z2110230, 2010ZA075, 2011ZDA013, 2011CB504400, 2012BAI13B06)
Topics
  • Social Sciences › Sociology and Political Science › Impact of Technology on Adolescents
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Keywords
internet addiction, dopamine transporter, striatum, 99mTc-TRODAT-1, dopaminergic dysfunction, neuroimaging, addiction
MeSH terms
Adolescent, Brain, Corpus Striatum, Humans, Male, Tropanes, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Case-Control Studies, Behavior, Addictive, Radiopharmaceuticals, Internet, Dopamine Plasma Membrane Transport Proteins, Young Adult

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