Role of the Microbiota and Antibiotics in Primary Sclerosing Cholangitis
Open accessAbstract
Primary sclerosing cholangitis (PSC) is an idiopathic, progressive, cholestatic liver disease with considerable morbidity and mortality and no established pharmacotherapy. In addition to the long-recognized association between PSC and inflammatory bowel disease, several lines of preclinical and clinical evidence implicate the microbiota in the etiopathogenesis of PSC. Here we provide a concise review of these data which, taken together, support further investigation of the role of the microbiota and antibiotics in PSC as potential avenues toward elucidating safe and effective pharmacotherapy for patients afflicted by this illness.
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Previous studies showing benefits of antibiotics in improving liver function in cholestatic patients point to an active role of the microbiome in mediating liver injury during cholestasis.
“Previous studies showing the benefits of antibiotics in improving liver function in cholestatic patients point to an active role of the microbiome in mediating liver injury during cholestasis21.”
From Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice (2019) · cites this paper as [21]
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References 75 · Cited by 91
- Authors
- Tabibian, J. H., Talwalkar, J. A., & Lindor, K. D.
- Affiliations
- Mayo Clinic (US)
- Arizona State University (US)
- Corresponding author
- Lindor, Keith D.
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2013
- Volume
- 2013
- Pages
- 1-7
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC3819830
- OpenAlex
- W2160798981
- Cited by
- 91
- References
- 75
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 11 · 2017: 13 · 2016: 11 · 2015: 9 · 2014: 4
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- primary sclerosing cholangitis, gut microbiota, antibiotics, inflammatory bowel disease, cholestatic liver disease, etiopathogenesis, pharmacotherapy
- MeSH terms
- Animals, Anti-Bacterial Agents, Disease Models, Animal, Humans, Cholangitis, Sclerosing, Inflammatory Bowel Diseases, Mice, Microbiota
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