The Effect of Varicocelectomy on Sperm Parameters in Subfertile Men with Clinical Varicoceles Who Have Asthenozoospermia or Teratozoospermia with Normal Sperm Density
Open accessAbstract
Background. To compare preoperative and postoperative sperm parameters such as sperm count, motility, and morphology in patients with normal sperm concentration with teratozoospermia and asthenozoospermia. Materials and Methods. Hundred and six patients with varicocele associated with male infertility over a 5-year period were included into the study. Pre- and postvaricocelectomy seminal fluid parameters evaluation according to the World Health Organization (WHO) criteria was performed at 4–6-month intervals. Results. One hundred and six patients met the criteria. The mean age of patients was 24.53 ± 8.13. The mean duration of infertility was 3.6 years (range: 1.5–6.3). Only the sperm motility of patients with normospermia showed a significant improvement postoperatively. Conclusions. No significant improvement in sperm morphology may be obtained in patients with clinical varicocele and preoperative normospermia.
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Several studies have evaluated the role of varicocelectomy and antioxidants in improving sperm morphology, particularly for immature sperm and those with head and tail defects based on Kruger's classification.
“Several studies have evaluated the role of varicocelectomy and antioxidants in improving sperm morphology, particularly for immature sperm and those with head and tail defects based on Kruger’s classification (97-104).”
From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [100]
The Methods and Results sections (pages not supplied) show that this study evaluated sperm morphology before and after varicocelectomy, supporting its inclusion as a study of that question. The Results found no significant improvement in morphology (P = 0.400). The paper does not evaluate antioxidant treatment or report outcomes for immature sperm or specific head and tail defects under Kruger’s classification. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIn men with clinical varicocele and pre-operative normal sperm density, varicocelectomy does not significantly improve sperm morphology.
“However, other studies have reported no significant improvement in sperm morphology after varicocelectomy in men with clinical varicocele and pre-operative normal sperm density (100,101).”
From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [100]
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Research works printed but not linked: 9
- [1]Cocuzza M Cocuzza MA Bragais FMP Agarwal A The role of varicocele repair in the new era of assisted reproductive technology Clinics 2008 63 3 395 404 2-s2.0-45749129470 18568252 PMC2664231
- [2]Agarwal A Deepinder F Cocuzza M Efficacy of varicocelectomy in improving semen parameters: new meta-analytical approach Urology 2007 70 3 532 538 2-s2.0-34648814355 17905111
- [3]Blumer CG Restelli AE Giudice PTD Effect of varicocele on sperm function and semen oxidative stress BJU International 2012 109 2 259 265 2-s2.0-84655162173 21592296
- [4]Abdel-Maguid A-F Othman I Microsurgical and nonmagnified subinguinal varicocelectomy for infertile men: a comparative study Fertility and Sterility 2010 94 7 2600 2603 2-s2.0-78649697566 20447629
- [5]WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction 2010 5th edition Cambridge, UK Cambridge University Press
- [6]Paduch DA Niedzielski J Repair versus observation in adolescent varicocele: a prospective study Journal of Urology 1997 158 3 1128 1132 2-s2.0-0030855203 9258155
- [7]Okeke L Ikuerowo O Chiekwe I Etukakpan B Shittu O Olapade-Olaopa O Is varicocelectomy indicated in subfertile men with clinical varicoceles who have asthenospermia or teratospermia and normal sperm density? International Journal of Urology 2007 14 8 729 732 2-s2.0-34547638600 17681064
- [8]Mancini A Meucci E Milardi D Seminal antioxidant capacity in pre- and postoperative varicocele Journal of Andrology 2004 25 1 44 49 2-s2.0-0346993071 14662785
- [9]Maciejko A Kim P Jang T Brannigan RE Lin WW Isolated teratospermia: is varicocelectomy indicated? Journal of Urology 2005 173 supplement 4 p. 369
Cited by
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Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review
Atmoko, W., Savira, M., Shah, R., Chung, E., & Agarwal, A. (2024) · Translational Andrology and Urology · doi:10.21037/tau-23-397 · Cited by 23 · see citing works
“However, other studies have reported no significant improvement in sperm morphology after varicocelectomy in men with clinical varicocele and pre-operative normal sperm density (100,101).”
- Authors
- Cakiroglu, B., Sinanoglu, O., & Gozukucuk, R.
- Affiliations
- Department of Urology, Hisar Intercontinental Hospital, Saray Mahallesi, Siteyolu Caddesi No. 7, Umraniye, 34768 Istanbul, Turkey
- Department of Urology, Maltepe University Medical School, Maltepe, 34844 Istanbul, Turkey
- Department of Infectious Diseases and Clinical Microbiology, Hisar Intercontinental Hospital, Saray Mahallesi, Siteyolu Caddesi No. 7, Umraniye, 34768 Istanbul, Turkey
- Venue
- ISRN Urology
- Publisher
- Wiley
- Published
- 2013-10-21
- Volume
- 2013
- Pages
- 1-3
- ISSN
- 2090-5807 (ISSN-L)
- 2090-5815
- PMC
- PMC3818894
- OpenAlex
- W2023392078
- Cited by
- 20
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 1
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- ISRN Urology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Health Professions › General Health Professions › Male Reproductive Health Studies
- Health Sciences › Medicine › Rheumatology › Urologic and reproductive health conditions
- Keywords
- varicocelectomy, varicocele, male infertility, asthenozoospermia, teratozoospermia, sperm motility, sperm morphology, sperm count, normospermia, semen parameters
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