Correlates of Adverse Outcomes in Abdominally Obese Individuals: Findings from the Five-Year Followup of the Population-Based Study of Health in Pomerania
Open accessAbstract
Background. Abdominal obesity is a major risk factor of cardiovascular disease (CVD), type 2 diabetes (T2DM), and premature death. However, it has not been resolved which factors predispose for the development of these adverse obesity-related outcomes in otherwise healthy individuals with abdominal obesity.Methods. We studied 1,506 abdominal obese individuals (waist-to-height ratio (WHtR) ≥ 0.5) free of CVD or T2DM from the population-based Study of Health in Pomerania and assessed the incidence of CVD or T2DM after a five-year followup. Logistic regression models were adjusted for major cardiovascular risk factors and liver, kidney diseases, and sociodemographic status.Results. During follow-up time, we observed 114 and 136 new T2DM and CVD cases, respectively. Regression models identified age, waist circumference, serum glucose, and liver disease as predictors of T2DM. Regarding CVD, only age, unemployment, and a divorced or widowed marital status were significantly associated with incident CVD. In this subgroup of obese individuals blood pressure, serum glucose, or lipids did not influence incidence of T2DM or CVD.Conclusion. We identified various factors associated with an increased risk of incident T2DM and CVD among abdominally obese individuals. These findings may improve the detection of high-risk individuals and help to advance prevention strategies in abdominal obesity.
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Hypertension and dyslipidemia serve as strong predictors for cardiovascular disease.
“Comparative analyses across complications reveal differing key predictors: retinal imaging features are critical for DR [154], renal function indicators are highly specific to DN [155], while hypertension and dyslipidemia serve as strong predictors for CVD [156] but also overlap with DR and DN [157].”
From Artificial intelligence-powered prediction of diabetic complications: from clinical data to molecular omics (2026) · cites this paper as [156]
The Results report associations between hypertension and cholesterol measures and incident CVD in an age-, sex-, and waist-adjusted analysis. But the multivariate analysis did not identify them as significant predictors, and the Discussion explicitly says blood pressure and lipid levels did not constitute CVD predictors in the abdominally obese subjects studied. (LLM, conf=0.90)
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- Authors
- Friedrich, N., Schneider, H. J., John, U., Dörr, M., Baumeister, S. E., Homuth, G., Völker, U., & Wallaschofski, H.
- Affiliations
- Universitätsmedizin Greifswald (DE)
- German Centre for Cardiovascular Research (DE)
- Corresponding author
- Friedrich, Nele
- Venue
- Journal of Obesity
- Publisher
- Wiley
- Published
- 2013
- Volume
- 2013
- Pages
- 1-7
- ISSN
- 2090-0708 (ISSN-L)
- 2090-0716
- PMC
- PMC3804035
- OpenAlex
- W1984857306
- Cited by
- 10
- References
- 25
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Obesity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- German Federal Ministry of Education and Research (01ZZ96030, 01ZZ0701)
- Ministry for Education, Research, and Cultural Affairs (01ZZ96030, 01ZZ0701)
- Ministry for Social Affairs of the Federal State of Mecklenburg—West Pomerania (01ZZ96030, 01ZZ0701)
- Deutsches Zentrum für Herz-Kreislauf-Forschung (01ZZ96030, 01ZZ0701)
- German Ministry of Education and Research (BMBF) (01ZZ96030, 01ZZ0701)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- abdominal obesity, waist-to-height ratio, type 2 diabetes, cardiovascular disease, liver disease, serum glucose, waist circumference, marital status, unemployment, Study of Health in Pomerania
- MeSH terms
- Adult, Aged, Blood Glucose, Blood Pressure, Body Height, Body Weight, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Germany, Humans, Lipids, Male, Middle Aged, Risk Factors, Cohort Studies, Body Mass Index, Logistic Models, Waist Circumference, Young Adult, Obesity, Abdominal
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