The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Roles of Inflammation, Oxidative Stress, and Vascular Dysfunction in Hypertension
Open accessAbstract
Hypertension is a complex condition and is the most common cardiovascular risk factor, contributing to widespread morbidity and mortality. Approximately 90% of hypertension cases are classified as essential hypertension, where the precise cause is unknown. Hypertension is associated with inflammation; however, whether inflammation is a cause or effect of hypertension is not well understood. The purpose of this review is to describe evidence from human and animal studies that inflammation leads to the development of hypertension, as well as the evidence for involvement of oxidative stress and endothelial dysfunction—both thought to be key steps in the development of hypertension. Other potential proinflammatory conditions that contribute to hypertension—such as activation of the sympathetic nervous system, aging, and elevated aldosterone—are also discussed. Finally, we consider the potential benefit of anti-inflammatory drugs and statins for antihypertensive therapy. The evidence reviewed suggests that inflammation can lead to the development of hypertension and that oxidative stress and endothelial dysfunction are involved in the inflammatory cascade. Aging and aldosterone may also both be involved in inflammation and hypertension. Hence, in the absence of serious side effects, anti-inflammatory drugs could potentially be used to treat hypertension in the future.
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Counter-regulatory renin–angiotensin system in cardiovascular disease
Paz Ocaranza, M., Riquelme, J. A., García, L., Jalil, J. E., Chiong, M., Santos, R. A. S., & Lavandero, S. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0244-8 · Cited by 561
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Endothelial permeability, LDL deposition, and cardiovascular risk factors—a review
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Nitric oxide bioavailability dysfunction involves in atherosclerosis
Chen, J.-Y., Ye, Z.-X., Wang, X.-F., Chang, J., Yang, M.-W., Zhong, H.-H., Hong, F.-F., & Yang, S.-L. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.10.122 · Cited by 216
Metadata
- Authors
- Dinh, Q. N., Drummond, G. R., Sobey, C. G., & Chrissobolis, S.
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-11
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- OpenAlex
- W2034845795
- Cited by
- 598
- References
- 15
- FWCI
- 16.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
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