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Cited by 117Lipoproteins and Cardiovascular HealthBiomarkers in Disease MechanismsInflammatory Biomarkers in Disease Prognosis

The DOI matches its Crossref record; 112 of the 113 references it cites were found in a registry or an index.

C-Reactive Protein: Clinical and Epidemiological Perspectives

Open access
Salazar, Juan, Martínez, María Sofía, Chávez, Mervin, Toledo, Alexandra, Añez, Roberto, Torres, Yaquelín, Apruzzese, Vanessa, Silva, Carlos, Rojas, Joselyn, Bermúdez, Valmore·2014·Cardiology Research and Practice
DOI 10.1155/2014/605810PMC PMC3932642
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Abstract

An important etiopathogenic component of cardiovascular disease is atherosclerosis, with inflammation being an essential event in the pathophysiology of all clinical pictures it comprises. In recent years, several molecules implicated in this process have been studied in order to assess cardiovascular risk in both primary and secondary prevention. C-reactive protein is a plasmatic protein of the pentraxin family and an acute phase reactant, very useful as a general inflammation marker. Currently, it is one of the most profoundly researched molecules in the cardiovascular field, yet its clinical applicability regarding cardiovascular risk remains an object of discussion, considered by some as a simple marker and by others as a true risk factor. In this sense, numerous studies propose its utilization as a predictor of cardiovascular risk through the use of high-sensitivity quantification methods for the detection of values <1 mg/L, following strict international guidelines. Increasing interest in these clinical findings has led to the creation of modified score systems including C-reactive protein concentrations, in order to enhance risk scores commonly used in clinical practice and offer improved care to patients with cardiovascular disease, which remains the first cause of mortality at the worldwide, national, and regional scenarios.

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Figure 1 Use of high-sensitivity CRP levels for the stratification of cardiovascular risk (primary prevention) and as a prognostic factor in acute coronary syndrome (secondary prevention) [69, 70].
Figure 1 Use of high-sensitivity CRP levels for the stratification of cardiovascular risk (primary prevention) and as a prognostic factor in acute coronary syndrome (secondary prevention) [69, 70].CC BY · PubMed Central
Figure 2 Models used to ascertain the role of an inflammatory marker.
Figure 2 Models used to ascertain the role of an inflammatory marker.CC BY · PubMed Central

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Show all 113 references

Research works printed but not linked: 19

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Metadata

Authors
Salazar, J., Martínez, M. S., Chávez, M., Toledo, A., Añez, R., Torres, Y., Apruzzese, V., Silva, C., Rojas, J., & Bermúdez, V.
Affiliations
  • Universidad del Zulia (VE)
  • Endocrine-Metabolic Research Center, “Dr. Félix Gómez”, Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, Venezuela
Corresponding author
Bermúdez, Valmore
ORCID
Venue
Cardiology Research and Practice
Publisher
Wiley
Published
2014
Volume
2014
Pages
1-10
ISSN
  • 2090-0597 (ISSN-L)
  • 2090-8016
DOI
10.1155/2014/605810
PMC
PMC3932642
OpenAlex
W1991015084
Cited by
117
References
113
Citations by year
2026: 3 · 2025: 4 · 2024: 9 · 2023: 5 · 2022: 13 · 2021: 10 · 2020: 11 · 2019: 11 · 2018: 9 · 2017: 12 · 2016: 15 · 2015: 11 · 2014: 4
FWCI
2.64
Type
journal article
Language
en
Open access
Licence
Locations
  • Cardiology Research and Practice (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords
C-reactive protein, cardiovascular risk, atherosclerosis, inflammation, acute phase proteins, pentraxins, high-sensitivity C-reactive protein, cardiovascular risk prediction, risk score, cardiovascular disease prevention

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