Clinical evaluation of various thyroid hormones on thyroid function
Open accessAbstract
To clarify the clinical value of serums total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), and free thyroxine (FT4) and provide a more eligible and economic strategy to assess thyroid function. A total of 2,673 participants (500 patients with hyperthyroidism, 500 patients with hypothyroidism, and 1,673 healthy people) were involved in our study. Serums TT3, TT4, FT3, and FT4 and thyrotropin (TSH) were measured with VIDAS fluorescent enzyme immunoassay. The Pearson correlation between TT3, TT4, FT3, and FT4 and TSH was determined to identify the most important indicator for thyroid function besides TSH. The correlation of TT4, and FT4 with TSH was statistically significant in healthy individuals (P < 0.01), and the R-values were -0.065 and -0.152, respectively. The correlation of TT4, FT4, TT3, and FT3 with TSH was statistically significant in patients with hyperthyroidism, and the R-values were -0.241, -0.225, -0.195, and -0.176, respectively. The correlation of TT4, FT4, TT3, and FT3 with TSH was statistically significant in patients with hypothyroidism, and the R-values were -0.322, -0.262, -0.179, and -0.136, respectively. In our opinion, TSH and FT4 are the most valuable indicators in assessing thyroid function in a healthy population, and TSH and TT4 are the most meaningful in hyperthyroidism and hypothyroidism.
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The lab test of FT4 is a more accurate evaluation of thyroid hormone concentration than measurement of total T3, T4 and FT3 due to limitations of measuring technique.
“The lab testof FT4 is considered as a more accurate evaluation of thyroid hormone concentration than the measurement of total T3, T4 and FT3 due to the limitation of measuring technique (67).”
From The progression of secondary diabetes: A review of modeling studies (2022) · cites this paper as [67]
The Discussion says the opposite of the claim's central comparison: because current FT4 measurements lack stability and accuracy, TT4 is better than FT4 for clinical measurement and thyroid-function assessment. It also describes FT4 measurement as indirect and less stable and repeatable than TT4. No page number is provided in our copy. (LLM, conf=0.94)
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References 32 · Cited by 35
- Authors
- Li, H., Yuan, X., Liu, L., Zhou, J., Li, C., Yang, P., Bu, L., Zhang, M., & Qu, S.
- Affiliations
- Tongji University (CN)
- Corresponding author
- Li, Hong
- Venue
- International Journal of Endocrinology
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-5
- ISSN
- 1687-8337 (ISSN-L)
- 1687-8345
- PMC
- PMC4274666
- OpenAlex
- W2008909345
- Cited by
- 35
- References
- 32
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 10 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 1
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (30700387)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- thyroid function assessment, free thyroxine, free triiodothyronine, total thyroxine, total triiodothyronine, thyroid-stimulating hormone, hyperthyroidism, hypothyroidism, thyroid hormones
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