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Cited by 170Rheumatoid Arthritis Research and TherapiesT-cell and B-cell ImmunologySystemic Lupus Erythematosus Research

B Cells in Rheumatoid Arthritis: From Pathogenic Players to Disease Biomarkers

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Bugatti, Serena, Vitolo, Barbara, Caporali, Roberto, Montecucco, Carlomaurizio, Manzo, Antonio·2014·BioMed Research International
DOI 10.1155/2014/681678PMC PMC4022166
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Abstract

The therapeutic benefit of depleting B cells in rheumatoid arthritis (RA) has refocused attention on B cells with increasing awareness on their role in autoimmunity and their function beyond autoantibody production. The rapid increase in our comprehension of B-cell pathobiology is progressively opening novel perspectives in the area of B cell-targeted therapies with the expectation to define more specific approaches able to preserve the homeostasis of the humoral response while disrupting the pathogenic components. In parallel, B-cell activity in RA is starting to be explored in its clinical value, in search of novel biomarkers embedded in the pathogenic process that could help classifying the disease and predicting its heterogeneous outcome beyond inflammation dynamics. In this review, we summarize current knowledge on the multiple roles that B cells play in several aspects of RA. We also analyze their distribution and potential function in different anatomic compartments with specific reference to the main sites in which the disease may be sustained and exert its detrimental effects: the systemic circulation, synovium, bone marrow, and draining lymph nodes. We also highlight novel data encouraging further research in the field of biomarkers related to B cells and their regulatory factors.

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  • B lymphocytes and autoantibodies are key in aspects of RA pathogenesis, and the clinical success of B cell targeted therapies further strengthens this.

    “It has recently been acknowledged that B lymphocytes and autoantibodies are key in aspects of RA pathogenesis [48, 49] and the clinical success of B cell targeted therapies further strengthens this [6, 50].”

    From The oncoprotein TBX3 is controlling severity in experimental arthritis (2019) · cites this paper as [49]

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Cited by

Sorted by citations

Authors
Bugatti, S., Vitolo, B., Caporali, R., Montecucco, C., & Manzo, A.
Affiliations
University of Pavia (IT)
Corresponding author
Bugatti, Serena
ORCID
Venue
BioMed Research International
Publisher
Wiley
Published
2014
Volume
2014
Pages
1-14
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
DOI
10.1155/2014/681678
PMC
PMC4022166
OpenAlex
W2021252940
Cited by
170
References
3
Citations by year
2026: 12 · 2025: 8 · 2024: 6 · 2023: 18 · 2022: 13 · 2021: 21 · 2020: 13 · 2019: 20 · 2018: 14 · 2017: 19 · 2016: 10 · 2015: 12 · 2014: 3 · 2013: 1
FWCI
2.41
Type
journal article
Language
en
Open access
Licence
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Italian Ministry of Health (GR-2009-1608032)
  • Fondazione Italiana per la Ricerca sull’Artrite FIRA Onlus (GR-2009-1608032)
Topics
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Keywords
rheumatoid arthritis, B cells, B-cell depletion, autoimmunity, B cell-targeted therapy, disease biomarkers, synovium, bone marrow, draining lymph nodes, systemic circulation, humoral immune response, disease heterogeneity
MeSH terms
Animals, Arthritis, Rheumatoid, Autoantibodies, B-Lymphocytes, Humans, Inflammation, Biomarkers

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