Biotechnological Production of Polyhydroxyalkanoates: A Review on Trends and Latest Developments
Open accessAbstract
Polyhydroxyalkanoates (PHA) producers have been reported to reside at various ecological niches which are naturally or accidently exposed to high organic matter or growth limited conditions such as dairy wastes, hydrocarbon contaminated sites, pulp and paper mill wastes, agricultural wastes, activated sludges of treatment plants, rhizosphere, and industrial effluents. Few among them also produce extracellular by-products like rhamnolipids, extracellular polymeric substances, and biohydrogen gas. These sorts of microbes are industrially important candidates for the reason that they can use waste materials of different origin as substrate with simultaneous production of valuable bioproducts including PHA. Implementation of integrated system to separate their by-products (intracellular and extracellular) can be economical in regard to production. In this review, we have discussed various microorganisms dwelling at different environmental conditions which stimulate them to accumulate carbon as polyhydroxyalkanoates granules and factors influencing its production and composition. A brief aspect on metabolites which are produced concomitantly with PHA has also been discussed. In conclusion, exploring of capabilities like of dual production by microbes and use of wastes as renewable substrate under optimized cultural conditions either in batch or continuous process can cause deduction in present cost of bioplastic production from stored PHA granules.
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Growth condition and strain selection can greatly affect cyanobacteria polyhydroxyalkanoates (PHAs) composition.
“For instance, the growth condition and strain selection can greatly affect cyanobacteria polyhydroxyalkanoates (PHAs) composition, polymers being used to generate biodegradable plastic [33].”
From Overview and Challenges of Large-Scale Cultivation of Photosynthetic Microalgae and Cyanobacteria (2023) · cites this paper as [33]
Section 2.3 reports that PHA production in cyanobacteria is species-specific and that growth conditions affect how much PHB they accumulate. It does not show that strain selection or growth conditions change the chemical composition of cyanobacterial PHAs; the composition discussion in the Introduction concerns PHA producers generally. Page numbers are not available in our copy. (LLM, conf=0.85)
Experimental — accuracy not yet measuredFor certain bacteria under optimized growth conditions, the yield of PHA obtained from the intracellular inclusions can be as high as 89% of the organism's dry weight.
“For certain bacteria under optimized growth condition, the yield of PHA obtained from the intracellular inclusions can be as high as 89% of the organism's dry weight.380”
From Catalysis as an Enabling Science for Sustainable Polymers (2018) · cites this paper as [380]
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References 181 · Cited by 144
Research works printed but not linked: 9
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- Authors
- Singh Saharan, B., Grewal, A., & Kumar, P.
- Affiliations
- Department of Microbiology, Kurukshetra University, Kurukshetra, Haryana 136 119, India
- Kurukshetra University (IN)
- Venue
- Chinese Journal of Biology
- Publisher
- Wiley
- Published
- 2014-02-24
- Volume
- 2014
- Pages
- 1-18
- ISSN
- 2314-7474 (ISSN-L)
- OpenAlex
- W1970996863
- Cited by
- 144
- References
- 181
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 6 · 2023: 12 · 2022: 22 · 2021: 26 · 2020: 9 · 2019: 9 · 2018: 11 · 2017: 17 · 2016: 8 · 2015: 6 · 2014: 3
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Chinese Journal of Biology (publishedVersion, cc-by)
- Funders
- Haryana State Council for Science and Technology
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Environmental Science › Pollution › Microbial bioremediation and biosurfactants
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biopolymer Synthesis and Applications
- Keywords
- polyhydroxyalkanoates, bioplastic production, waste substrates, dairy waste, hydrocarbon-contaminated sites, pulp and paper industry waste, agricultural waste, activated sludge, rhizosphere, rhamnolipids, extracellular polymeric substances, biohydrogen, PHA granules, continuous fermentation
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