Synthesis and characterization of chemically cross-linked acrylic acid/gelatin hydrogels: effect of pH and composition on swelling and drug release
Open accessAbstract
This present work was aimed at synthesizing pH-sensitive cross-linked AA/Gelatin hydrogels by free radical polymerization. Ammonium persulfate and ethylene glycol dimethacrylate (EGDMA) were used as initiator and as cross-linking agent, respectively. Different feed ratios of acrylic acid, gelatin, and EGDMA were used to investigate the effect of monomer, polymer, and degree of cross-linking on swelling and release pattern of the model drug. The swelling behavior of the hydrogel samples was studied in 0.05 M USP phosphate buffer solutions of various pH values pH 1.2, pH 5.5, pH 6.5, and pH 7.5. The prepared samples were evaluated for porosity and sol-gel fraction analysis. Pheniramine maleate used for allergy treatment was loaded as model drug in selected samples. The release study of the drug was investigated in 0.05 M USP phosphate buffer of varying pH values (1.2, 5.5, and 7.5) for 12 hrs. The release data was fitted to various kinetic models to study the release mechanism. Hydrogels were characterized by Fourier transformed infrared (FTIR) spectroscopy which confirmed formation of structure. Surface morphology of unloaded and loaded samples was studied by surface electron microscopy (SEM), which confirmed the distribution of model drug in the gel network.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Copolymeric networks containing acrylic acid swell appreciably at physiological pH 7.4 due to deprotonation of carboxylic acid groups, causing pH-responsiveness.
“Copolymeric networks containing AA due to their polyanionic nature swell appreciably at the physiological pH (7.4) due to deprotonation of carboxylic acid groups causing pH-responsiveness.”
From A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled drug delivery. (2023) · cites this paper as Bukhari et al., 2015
The pH-controlled release abilities of acrylic acid-containing copolymeric networks can be modified by changing the polymeric composition.
“Their actual pH-controlled release abilities can be modified by changing the polymeric composition (Bukhari et al., 2015).”
From A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled drug delivery. (2023) · cites this paper as Bukhari et al., 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 42 · Cited by 231
- Authors
- Bukhari, S. M. H., Khan, S., Rehanullah, M., & Ranjha, N. M.
- Affiliations
- Bahauddin Zakariya University (PK)
- COMSATS University Islamabad (PK)
- Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan
- Corresponding author
- Khan, Samiullah
- ORCID
- Khan, Samiullah
- Venue
- International Journal of Polymer Science
- Publisher
- Wiley
- Published
- 2015
- Volume
- 2015
- Pages
- 1-15
- ISSN
- 1687-9422 (ISSN-L)
- 1687-9430
- OpenAlex
- W2108077920
- Cited by
- 231
- References
- 42
- Citations by year
- 2026: 13 · 2025: 34 · 2024: 28 · 2023: 25 · 2022: 37 · 2021: 28 · 2020: 25 · 2019: 19 · 2018: 13 · 2017: 6 · 2016: 2 · 2015: 1
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Polymer Science (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Peshawar
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- chemically crosslinked hydrogels, pH-responsive hydrogels, swelling behavior, drug release, pheniramine maleate, ethylene glycol dimethacrylate, crosslink density, release kinetics, porosity, radical polymerization
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
