Regulatory role of small nucleolar RNAs in human diseases
Open accessAbstract
Small nucleolar RNAs (snoRNAs) are appreciable players in gene expression regulation in human cells. The canonical function of box C/D and box H/ACA snoRNAs is posttranscriptional modification of ribosomal RNAs (rRNAs), namely, 2′-O-methylation and pseudouridylation, respectively. A series of independent studies demonstrated that snoRNAs, as well as other noncoding RNAs, serve as the source of various short regulatory RNAs. Some snoRNAs and their fragments can also participate in the regulation of alternative splicing and posttranscriptional modification of mRNA. Alterations in snoRNA expression in human cells can affect numerous vital cellular processes. SnoRNA level in human cells, blood serum, and plasma presents a promising target for diagnostics and treatment of human pathologies. Here we discuss the relation between snoRNAs and oncological, neurodegenerative, and viral diseases and also describe changes in snoRNA level in response to artificial stress and some drugs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Various types of ncRNAs including snoRNAs can also participate in the regulation of gene expression, cell cycle, DNA repair, genome integrity, as well as in human diseases.
“Accumulating evidence suggested that various types of ncRNAs including snoRNAs can also participate in the regulation of gene expression, cell cycle, DNA repair, genome integrity, as well as in human diseases [71,72]”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 97 · Cited by 154
- Authors
- Stepanov, G. A., Filippova, J. A., Komissarov, A. B., Kuligina, E. V., Richter, V. A., & Semenov, D. V.
- Affiliations
- Institute of Chemical Biology and Fundamental Medicine (RU)
- Novosibirsk State University (RU)
- St Petersburg University (RU)
- Corresponding author
- Stepanov, Grigory A.
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2015
- Volume
- 2015
- Pages
- 1-10
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC4427830
- OpenAlex
- W2044575338
- Cited by
- 154
- References
- 97
- Citations by year
- 2025: 9 · 2024: 14 · 2023: 12 · 2022: 20 · 2021: 14 · 2020: 19 · 2019: 16 · 2018: 17 · 2017: 18 · 2016: 11 · 2015: 4
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Russian Foundation for Basic Research (14-04-31468, 14-34-50408, 13-04-01058)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- small nucleolar RNA, box C/D snoRNA, box H/ACA snoRNAs, ribosomal RNA modification, 2'-O-methylation, pseudouridylation, alternative splicing, non-coding RNA, cancer, neurodegenerative diseases, viral infection, stress response, serum and plasma biomarkers
- MeSH terms
- Animals, Disease, Gene Expression Regulation, Humans, Neoplasms, Nucleic Acid Conformation, RNA Processing, Post-Transcriptional, RNA, Neoplasm, Stress, Physiological, Virus Diseases, Heredodegenerative Disorders, Nervous System, RNA, Small Nucleolar
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
