Profiling of Selected MicroRNAs in Proliferative Eutopic Endometrium of Women with Ovarian Endometriosis
Open accessAbstract
It has been well documented that aberrant expression of selected microRNAs (miRNAs) might contribute to the pathogenesis of disease. The aim of the present study is to compare miRNA expression by the most comprehensive locked-nucleic acid (LNA) miRNA microarray in eutopic endometrium of patients with endometriosis and control. In the study we recruited 21 patients with endometriosis and 25 were disease-free women. The miRNA expression profiles were determined using the LNA miRNA microarray and validated for selected molecules by real-time PCR. We identified 1198 human miRNAs significantly differentially altered in endometriosis versus control samples using false discovery rate of <5%. However only 136 miRNAs showed differential regulation by fold change of at least 1.3. By the use of selected statistical analysis we obtained 45 potential pathways that might play a role in the pathogenesis of endometriosis. We also found that natural killer cell mediated cytotoxicity pathway was found to be inhibited which is consistent with previous studies. There are several pathways that may be potentially dysregulated, due to abnormal miRNA expression, in eutopic endometrium of patients with endometriosis and in this way contribute to its pathogenesis.
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In miRNA profiling of eutopic endometrium from women with endometriosis, two miRNAs were elevated and 13 had reduced expression compared to control.
“A sample of 667 human miRNAs were studied in patients with endometriosis compared to the control group. Two of the study miRNAs were elevated, while 13 miRNAs had reduced levels of expression in eutopic endometrium in endometriosis patients compared to control.”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [162]
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References 43 · Cited by 48
- Authors
- Laudanski, P., Charkiewicz, R., Tolwinska, A., Szamatowicz, J., Charkiewicz, A., & Niklinski, J.
- Affiliations
- Department of Perinatology, Medical University of Bialystok, Ulica Marii Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland
- Medical University of Białystok (PL)
- Clinic “EDMED” Białystok, Ul. Piasta 14, 15-044 Bialystok, Poland
- Department of Clinical Molecular Biology, Medical University of Bialystok, Ul. Waszyngtona 13, 15-269 Bialystok, Poland
- Venue
- BioMed Research International
- Publisher
- Hindawi Limited
- Published
- 2015
- Volume
- 2015
- Pages
- 1-10
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC4558423
- OpenAlex
- W1622700982
- Cited by
- 48
- References
- 43
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 5 · 2016: 4
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- miRNA expression profiling, endometrioma, eutopic endometrium, endometriosis pathogenesis, differentially expressed miRNAs, NK cell cytotoxicity
- MeSH terms
- Adult, Endometriosis, Endometrium, Female, Humans, Ovary, Case-Control Studies, Gene Expression Profiling, MicroRNAs, Cell Proliferation
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