The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
The Genetic and Environmental Factors for Keratoconus
Open accessAbstract
Keratoconus (KC) is the most common cornea ectatic disorder. It is characterized by a cone-shaped thin cornea leading to myopia, irregular astigmatism, and vision impairment. It affects all ethnic groups and both genders. Both environmental and genetic factors may contribute to its pathogenesis. This review is to summarize the current research development in KC epidemiology and genetic etiology. Environmental factors include but are not limited to eye rubbing, atopy, sun exposure, and geography. Genetic discoveries have been reviewed with evidence from family-based linkage analysis and fine mapping in linkage region, genome-wide association studies, and candidate genes analyses. A number of genes have been discovered at a relatively rapid pace. The detailed molecular mechanism underlying KC pathogenesis will significantly advance our understanding of KC and promote the development of potential therapies.
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Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
Investigative Ophthalmology and Visual Science
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Corneal Collagen Crosslinking: A Systematic Review
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Exome sequencing as a tool for Mendelian disease gene discovery
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Keratoconus and related noninflammatory corneal thinning disorders
Krachmer, J. H., Feder, R. S., & Belin, M. W. (1984) · Survey of Ophthalmology · doi:10.1016/0039-6257(84)90094-8 · Cited by 1,598
Genomewide Association Studies and Assessment of the Risk of Disease
Manolio, T. A. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0905980 · Cited by 1,512
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A 48-Year Clinical and Epidemiologic Study of Keratoconus
Kennedy, R. H., Bourne, W. M., & Dyer, J. A. (1986) · American Journal of Ophthalmology · doi:10.1016/0002-9394(86)90817-2 · Cited by 966
Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: Long-term results
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Metadata
- Authors
- Gordon-Shaag, A., Millodot, M., Shneor, E., & Liu, Y.
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2015
- Volume
- 2015
- Pages
- 1-19
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- OpenAlex
- W1572654736
- Cited by
- 428
- References
- 121
- FWCI
- 14.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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