The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Dengue Fever: Causes, Complications, and Vaccine Strategies
Open accessAbstract
Dengue is a highly endemic infectious disease of the tropical countries and is rapidly becoming a global burden. It is caused by any of the 4 serotypes of dengue virus and is transmitted within humans through female Aedes mosquitoes. Dengue disease varies from mild fever to severe conditions of dengue hemorrhagic fever and shock syndrome. Globalization, increased air travel, and unplanned urbanization have led to increase in the rate of infection and helped dengue to expand its geographic and demographic distribution. Dengue vaccine development has been a challenging task due to the existence of four antigenically distinct dengue virus serotypes, each capable of eliciting cross-reactive and disease-enhancing antibody response against the remaining three serotypes. Recently, Sanofi Pasteur’s chimeric live-attenuated dengue vaccine candidate has been approved in Mexico, Brazil, and Philippines for usage in adults between 9 and 45 years of age. The impact of its limited application to the public health system needs to be evaluated. Simultaneously, the restricted application of this vaccine candidate warrants continued efforts in developing a dengue vaccine candidate which is additionally efficacious for infants and naïve individuals. In this context, alternative strategies of developing a designed vaccine candidate which does not allow production of enhancing antibodies should be explored, as it may expand the umbrella of efficacy to include infants and naïve individuals.
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The global distribution and burden of dengue
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“A recent dengue distribution model has estimated 390 million dengue infections annually, out of which 96million cases occurred apparently [6, 7].”
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The global burden of dengue: an analysis from the Global Burden of Disease Study 2013
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Efficacy and Long-Term Safety of a Dengue Vaccine in Regions of Endemic Disease
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Cross-Reacting Antibodies Enhance Dengue Virus Infection in Humans
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Efficacy of a Tetravalent Dengue Vaccine in Children in Latin America
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Human skin Langerhans cells are targets of dengue virus infection
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Cited by
Digital Health Interventions in Dengue Surveillance to Detect and Predict Outbreak: A Scoping Review
Salim, M. F., Satoto, T. B. T., ., D., & Daniel, D. (2024) · The Open Public Health Journal · doi:10.2174/0118749445283264240116070726 · Cited by 13
Metadata
- Authors
- Khetarpal, N., & Khanna, I.
- Venue
- Journal of Immunology Research
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-14
- ISSN
- 2314-7156 (ISSN-L)
- 2314-8861
- OpenAlex
- W2479953748
- Cited by
- 363
- References
- 52
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- gold
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