Effect on insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator during weight loss in obese women with and without polycystic ovary syndrome
Open accessAbstract
Background.A deficiency of D-chiro-inositol-inositolphosphoglycan mediator (DCI-IPG) may contribute to insulin resistance in polycystic ovary syndrome (PCOS). Whether the relationship between impaired DCI-IPG release and insulin resistance is specific to PCOS rather than obesity is unknown. We assessed insulin-released DCI-IPG and its relationship to insulin sensitivity at baseline and after weight loss in obese women with and without PCOS.Methods.Obese PCOS ( n=16 ) and normal ( n=15 ) women underwent 8 weeks of a hypocaloric diet. The Matsuda index, area under the curve DCI-IPG ( AUCDCI-IPG ), AUCinsulin , and AUCDCI-IPG/AUCinsulin were measured during a 2 hr OGTT at baseline and 8 weeks.Results.PCOS women had lower AUCDCI-IPG/AUCinsulin at baseline and a significant relationship between AUCDCI-IPG/AUCinsulin and Matsuda index ( p=0.0003 ), which was not present in controls. Weight loss was similar between PCOS (−4.08 kg) and normal women (−4.29 kg, p=0.6281 ). Weight loss in PCOS women did not change the relationship between AUCDCI-IPG/AUCinsulin and Matsuda index ( p=0.0100 ), and this relationship remained absent in control women.Conclusion.The association between AUCDCI-IPG/AUCinsulin and insulin sensitivity was only found in PCOS but not in normal women, and this relationship was unaffected by weight loss. DCI and its messenger may contribute to insulin resistance in PCOS independent of obesity.
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Three studies reported that there was no statistically significant difference in fasting glucose post-intervention between the two groups.
“The majority of studies did not report whether there were between-group statistical significance, and three studies [35,43,44] reported that there was no statistically significant difference in fasting glucose post-intervention between the two groups (Table 4).”
From Weight management interventions in women with and without PCOS: a systematic review (2017) · cites this paper as [43]
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References 32 · Cited by 2
- Authors
- Cheang, K. I., Sistrun, S. N., Morel, K. S., & Nestler, J. E.
- Affiliations
- Virginia Commonwealth University (US)
- Carilion Clinic (US)
- Corresponding author
- Cheang, Kai I.
- ORCID
- Cheang, Kai I.
- Venue
- International Journal of Endocrinology
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-7
- ISSN
- 1687-8337 (ISSN-L)
- 1687-8345
- PMC
- PMC5046020
- OpenAlex
- W2519135216
- Cited by
- 2
- References
- 32
- Citations by year
- 2023: 1 · 2017: 1
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health Grant (K23 K23HD049454, ULTR000058)
- CTSA (K23 K23HD049454, ULTR000058)
- National Center for Advancing Translational Sciences (K23 K23HD049454, ULTR000058)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- D-chiro-inositol, insulin resistance, polycystic ovary syndrome, obesity, weight loss, insulin sensitivity, Matsuda index, hypocaloric diet, glucose tolerance
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