Roles of oxidative stress in polycystic ovary syndrome and cancers
Open accessAbstract
Oxidative stress (OS) has received extensive attention in the last two decades, because of the discovery that abnormal oxidation status was related to patients with chronic diseases, such as diabetes, cardiovascular, polycystic ovary syndrome (PCOS), cancer, and neurological diseases. OS is considered as a potential inducing factor in the pathogenesis of PCOS, which is one of the most common complex endocrine disorders and a leading cause of female infertility, affecting 4%-12% of women in the world, as OS has close interactions with PCOS characteristics, just as insulin resistance (IR), hyperandrogenemia, and chronic inflammation. It has also been shown that DNA mutations and alterations induced by OS are involved in cancer pathogenesis, tumor cell survival, proliferation, invasion, angiogenesis, and so on. Furthermore, recent studies show that the females with PCOS are reported to have an increasing risk of cancers. As a result, the more serious OS in PCOS is regarded as an important potential incentive for the increasing risk of cancers, and this study aims to analyze the possibility and potential pathogenic mechanism of the above process, providing insightful thoughts and evidences for preventing cancer potentially caused by PCOS in clinic.
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PCOS involves two-way relationships between androgen excess, adipose dysfunction, IR, inflammation, and oxidative stress.
“However, this process has several vicious circles, with two-way relationships between androgen excess, adipose dysfunction, IR, and other actors, such as inflammation [24], and oxidative stress [25,26]”
From PCOS and nutritional approaches: Differences between lean and obese phenotype (2021) · cites this paper as [25]
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References 197 · Cited by 319
Research works printed but not linked: 6
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- Authors
- Zuo, T., Zhu, M., & Xu, W.
- Affiliations
- Chinese University of Hong Kong (HK)
- Second Affiliated Hospital of Chengdu University of Traditional Chinese (CN)
- Corresponding author
- Xu, Wenming
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2015-12-06
- Volume
- 2016
- Issue
- 1
- Pages
- 8589318-8589318
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC4684888
- OpenAlex
- W1897491882
- Cited by
- 319
- References
- 197
- Citations by year
- 2026: 17 · 2025: 31 · 2024: 44 · 2023: 47 · 2022: 45 · 2021: 33 · 2020: 32 · 2019: 31 · 2018: 24 · 2017: 11 · 2016: 4
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- oxidative stress, polycystic ovary syndrome, cancer risk, female infertility, insulin resistance, hyperandrogenemia, chronic inflammation, DNA damage, tumor angiogenesis, cancer prevention
- MeSH terms
- Animals, Female, Humans, Models, Biological, Neoplasms, Polycystic Ovary Syndrome, Oxidative Stress
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