The Preventive Effect of Zuogui Wan on Offspring Rats’ Impaired Glucose Tolerance Whose Mothers Had Gestational Diabetes Mellitus
Open accessAbstract
In this experiment, we used streptozotocin (STZ) to establish a model of gestational diabetes mellitus (GDM) rats, where Zuogui Wan was given to GDM rats. After pregnancy, offspring rats were divided into 4 groups: control group, high fat and sugar as the control group, GDM group, and Zuogui Wan GDM group. Rats in high fat and sugar as the control group, GDM group, and Zuogui Wan GDM group were fed with high fat and sugar diet. Rats in control group were fed the basic diet. The means of 2hPG were higher than 7.8 mmol·L−1 and lower than 11.1 mmol·L−1 on the rats of GDM group on week 15, and IGT models were successful. Body weight, abdominal fat weight, the ratio of abdominal fat weight and body weight, fasting plasma glucose, 2hPG, insulin, leptin, total cholesterol, and low density lipoprotein (LDL) of Zuogui Wan GDM group were significantly lower than GDM group. The level of adiponectin in Zuogui Wan GDM group was significantly higher than GDM group. And we concluded that giving Zuogui Wan to GDM rats can have a preventive effect on the offsprings’ IGT induced by high fat and sugar diet.
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In offspring of Zuo Gui Wan-treated GDM mice fed a high fat and sugar diet, Zuo Gui Wan treatment protected against high levels of fasting plasma glucose, insulin, leptin, total cholesterol, and low-density lipoprotein.
“Furthermore, the same group found that when the offspring of Zuo Gui Wan-treated GDM mice were fed a high fat and sugar diet, they were protected against high levels of fasting plasma glucose, insulin, leptin, total cholesterol, and low-density lipoprotein [23].”
From Evaluating Traditional Chinese Medicine and Herbal Products for the Treatment of Gestational Diabetes Mellitus (2019) · cites this paper as [23]
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References 9 · Cited by 16
Research works printed but not linked: 1
- [9]Xu K. Wang Y. Yang X. Niu X. Liu Y. Feng Q. Effect of tonifying kidney recipes on the generation of mice nonspecific immune function Journal of Clinical Laboratory Science China 2012 9 161 164
- Authors
- Wang, Y., Feng, Q., Niu, X., Xu, K., Wang, Y., Wang, J., Li, Q., Mao, Y., & Gao, S.
- Affiliations
- Beijing University of Chinese Medicine (CN)
- Shanxi University of Traditional Chinese Medicine (CN)
- Zhejiang University (CN)
- China Academy of Chinese Medical Sciences (CN)
- Corresponding author
- Feng, Qianjin
- Venue
- Evidence-Based Complementary and Alternative Medicine
- Publisher
- Wiley
- Published
- 2016-01
- Volume
- 2016
- Issue
- 1
- Pages
- 9417362-9417362
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- PMC
- PMC4789487
- OpenAlex
- W2289399860
- Cited by
- 16
- References
- 9
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 2
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Science and Technology Cooperation Projects (0102012DFA31330)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- gestational diabetes mellitus, impaired glucose tolerance, offspring, high-fat high-sugar diet, streptozotocin-induced diabetes, adiponectin, leptin, insulin, abdominal fat, lipid profile, traditional Chinese medicine, prevention
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