Cellular and Molecular Mechanisms of Arrhythmia by Oxidative Stress
Open accessAbstract
Current therapies for arrhythmia using ion channel blockade, catheter ablation, or an implantable cardioverter defibrillator have limitations, and it is important to search for new antiarrhythmic therapeutic targets. Both atrial fibrillation and heart failure, a condition with increased arrhythmic risk, are associated with excess amount of reactive oxygen species (ROS). There are several possible ways for ROS to induce arrhythmia. ROS can cause focal activity and reentry. ROS alter multiple cardiac ionic currents. ROS promote cardiac fibrosis and impair gap junction function, resulting in reduced myocyte coupling and facilitation of reentry. In order to design effective antioxidant drugs for treatment of arrhythmia, it is essential to explore the molecular mechanisms by which ROS exert these arrhythmic effects. Activation of Ca 2+/CaM-dependent kinase II, c-Src tyrosine kinase, protein kinase C, and abnormal splicing of cardiac sodium channels are among the recently discovered molecular mechanisms of ROS-induced arrhythmia.
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Prolonged exposure to reactive oxygen species from oxidative stress has been associated with vascular and cardiac myocyte dysfunction, which may lead to cardiac arrhythmias through cardiac fibrosis, ion-channel conduction disturbances, and early and late depolarisations.
“Prolonged exposure to reactive oxygen species from oxidative stress has been associated with vascular and cardiac myocyte dysfunction, which may lead to cardiac arrhythmias through cardiac fibrosis, ion-channel conduction disturbances, and early and late depolarisations. 38,39”
From Risk of cardiovascular outcomes among women with endometriosis in the United Kingdom: a retrospective matched cohort study (2021) · cites this paper as [38]
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References 72 · Cited by 126
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- [19]Sovari A. A. Dudley S. C. Sauer H. Ajay M. S. Laurindo F. R. Atrial fibrillation and oxidative stress Studies in Cardiovascular Disorders 2010 1st New York, NY, USA Humana Press 373 389
- [28]Morita N. Sovari A. A. Xie Y. Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress American Journal of Physiology—Heart and Circulatory Physiology 2009 297 5 H1594 H1605 10.1152/ajpheart.00579.2009 2-s2.0-70350455536 19767530 PMC2781379 · DOI
- [30]Sovari A. A. Iravanian S. Mitchell D. Mitochondria-targeted antioxidant, mito-tempo, prevents angiotensin II mediated connexin 43 remodeling and sudden cardiac death Journal of Investigative Medicine 2011 59 692 730
- [58]Sovari A. A. Iravanian S. Mitchell D. Mitochondria-targeted antioxidant, Mito-TEMPO, prevents angiotensin II mediated connexin 43 remodeling and sudden cardiac death Journal of Investigative Medicine 2011 59 692 730
- [67]Sovari A. A. Morita N. Weiss J. N. Karagueuzian H. Oxidative stress promotes ventricular fibrillation in spontaneously hypertensive rats by a Ca2+/CaM dependent kinase-II signaling pathway Journal of the American College of Cardiology 2009 53 A101 A102
- Authors
- Sovari, A. A.
- Affiliations
- Cedars-Sinai Medical Center (US)
- Corresponding author
- Sovari, Ali A.
- Venue
- Cardiology Research and Practice
- Publisher
- Wiley
- Published
- 2016
- Volume
- 2016
- Pages
- 1-7
- ISSN
- 2090-0597 (ISSN-L)
- 2090-8016
- PMC
- PMC4770129
- OpenAlex
- W2281322433
- Cited by
- 126
- References
- 72
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 11 · 2023: 18 · 2022: 13 · 2021: 17 · 2020: 12 · 2019: 11 · 2018: 10 · 2017: 10 · 2016: 6
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cardiology Research and Practice (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Keywords
- oxidative stress, reactive oxygen species, cardiac arrhythmias, atrial fibrillation, heart failure, reentry, myocardial fibrosis, antioxidant drugs, CaMKII, c-Src kinase, protein kinase C
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