Interleukin-7 and Immunosenescence
Open accessAbstract
The age of an individual is an important, independent risk factor for many of the most common diseases afflicting modern societies. Interleukin-7 (IL-7) plays a central, critical role in the homeostasis of the immune system. Recent studies support a critical role for IL-7 in the maintenance of a vigorous healthspan. We describe the role of IL-7 and its receptor in immunosenescence, the aging of the immune system. An understanding of the role that IL-7 plays in aging may permit parsimonious preventative or therapeutic solutions for diverse conditions. Perhaps IL-7 might be used to “tune” the immune system to optimize human healthspan and longevity.
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IL-7 and its receptors play a key role in immunosenescence, affecting the balance of the immune system.
“Indeed, some potential targets were already investigated: a recent study has reported that interleukin (IL)-7 and its receptors play a key role in immunosenescence, affecting the balance of the immune system [30] (Fig. 2).”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [30]
The reduction of T cell output caused by thymic degeneration can be achieved through intervention with immune regulatory factors, i.e., by supplementing IL-7, thereby restoring T cell production and thymic function.
“First, the reduction of T cell output caused by thymic degeneration can be achieved through the intervention with immune regulatory factors, i.e., by supplementing IL-7 [30], thereby restoring T cell production and thymic function.”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [30]
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References 165 · Cited by 96
- Authors
- Nguyen, V., Mendelsohn, A., & Larrick, J. W.
- Affiliations
- Panorama Research (United States) (US)
- Corresponding author
- Nguyen, Vanloan
- Venue
- Journal of Immunology Research
- Publisher
- Wiley
- Published
- 2017
- Volume
- 2017
- Pages
- 1-17
- ISSN
- 2314-7156 (ISSN-L)
- 2314-8861
- PMC
- PMC5397725
- OpenAlex
- W2604627240
- Cited by
- 96
- References
- 165
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 15 · 2023: 9 · 2022: 15 · 2021: 15 · 2020: 11 · 2019: 5 · 2018: 7 · 2017: 3
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Immunology Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- IL-7, immunosenescence, IL-7 receptor, healthspan, longevity, immune homeostasis, age-related disease risk
- MeSH terms
- Immunosenescence, Aging, Animals, Homeostasis, Humans, Inflammation, Longevity, Signal Transduction, Interleukin-7, Receptors, Interleukin-7, Mice
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