Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association
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Purpose. This study was aimed at evaluating sirtuin 4 (Sirt4) levels in obese individuals, in relation to their adherence to the Mediterranean diet (MD), a healthy dietary pattern characterized by high antioxidant capacity, and markers of visceral fat storage. Subjects/Methods. Forty‐three obese patients (44% males; BMI: 36.7–58.8 kg/m 2) were consecutively included. PREvención con DIeta MEDiterránea (PREDIMED) and the 7‐day food records were used to assess the adherence to MD and dietary pattern, respectively. Visceral adiposity index (VAI) was calculated. Sirt4 levels were detected by ELISA method. Results. The majority of the obese participants (62.8%) had an average adherence to MD. Compared with average adherers, low adherers had higher BMI, energy intake, and percentage of energy from lipids, mainly saturated fat and polyunsaturated fatty acids (PUFA), and lower Sirt4 levels. After adjusting for BMI, Sirt4 levels remained negatively correlated with VAI. After adjusting for total energy intake, Sirt4 levels remained negatively associated with PREDIMED and consumption of n‐3 PUFA, vitamins C and E. The threshold value of PREDIMED predicting the lowest decrease in Sirt4 levels was found at a score of 6. Conclusions. Less reduced Sirt4 levels in obese patients adhering to MD suggest a further aspect of the antioxidant advantage of MD.
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Individuals with obesity and low adherence to the Mediterranean diet presented worse anthropometric measurements and metabolic profile compared with subjects who were good sleepers and with an average adherence, independently of age and gender.
“Some reports examine the adherence to MD and have shown that individuals with obesity and with low adherence to MD presented worse anthropometric measurements and metabolic profile compared with subjects who were good sleepers and with an average adherence, independently of age and gender [88, 122, 127].”
From Mediterranean Diet and Obesity-related Disorders: What is the Evidence? (2022) · cites this paper as [122]
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References 43 · Cited by 60
Research works printed but not linked: 1
- [40]Thompson F. E. Subar AF Chapter 1—Dietary Assessment Methodology. Nutrition in the Prevention and Treatment of Disease 2008 Burlington Academic Press
- Authors
- Barrea, L., Tarantino, G., Somma, C. D., Muscogiuri, G., Macchia, P. E., Falco, A., Colao, A., & Savastano, S.
- Affiliations
- Federico II University Hospital (IT)
- SDN Istituto di Ricerca Diagnostica e Nucleare (IT)
- Corresponding author
- Tarantino, Giovanni
- ORCID
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2017-01
- Volume
- 2017
- Issue
- 1
- Pages
- 6101254-6101254
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC5494780
- OpenAlex
- W2625202156
- Cited by
- 60
- References
- 43
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 7 · 2022: 9 · 2021: 16 · 2020: 5 · 2019: 7 · 2018: 4
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Italian Ministry for University and Research (PRIN 2012)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- Mediterranean diet, obesity, dietary adherence, visceral adiposity index, omega-3 fatty acids, antioxidants, PREDIMED, circulating biomarkers, energy intake
- MeSH terms
- Cross-Sectional Studies, Female, Humans, Male, Obesity, Risk Factors, Mitochondrial Proteins, Sirtuins, Diet, Mediterranean
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