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Cited by 62Electrospun Nanofibers in Biomedical ApplicationsTissue Engineering and Regenerative MedicineSilk-based biomaterials and applications

Vascular Tissue Engineering: Effects of Integrating Collagen into a PCL Based Nanofiber Material

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Bertram, Ulf, Steiner, Dominik, Poppitz, Benjamin, Dippold, Dirk, Köhn, Katrin, Beier, Justus P., Detsch, Rainer, Boccaccini, Aldo R. +3 more·2017·BioMed Research International
DOI 10.1155/2017/9616939PMC PMC5592415
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Abstract

The engineering of vascular grafts is a growing field in regenerative medicine. Although numerous attempts have been made, the current vascular grafts made of polyurethane (PU), Dacron®, or Teflon® still display unsatisfying results. Electrospinning of biopolymers and native proteins has been in the focus of research to imitate the extracellular matrix (ECM) of vessels to produce a small caliber, off-the-shelf tissue engineered vascular graft (TEVG) as a substitute for poorly performing PU, Dacron, or Teflon prostheses. Blended poly-ε-caprolactone (PCL)/collagen grafts have shown promising results regarding biomechanical and cell supporting features. In order to find a suitable PCL/collagen blend, we fabricated plane electrospun PCL scaffolds using various collagen type I concentrations ranging from 5% to 75%. We analyzed biocompatibility and morphological aspects in vitro. Our results show beneficial features of collagen I integration regarding cell viability and functionality, but also adverse effects like the loss of a confluent monolayer at high concentrations of collagen. Furthermore, electrospun PCL scaffolds containing 25% collagen I seem to be ideal for engineering vascular grafts.

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Authors
Bertram, U., Steiner, D., Poppitz, B., Dippold, D., Köhn, K., Beier, J. P., Detsch, R., Boccaccini, A. R., Schubert, D. W., Horch, R. E., & Arkudas, A.
Affiliations
Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Corresponding author
Arkudas, Andreas
ORCID
Venue
BioMed Research International
Publisher
Wiley
Published
2017
Volume
2017
Pages
1-11
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
DOI
10.1155/2017/9616939
PMC
PMC5592415
OpenAlex
W2748663702
Cited by
62
References
1
Citations by year
2026: 2 · 2025: 5 · 2024: 8 · 2023: 6 · 2022: 9 · 2021: 9 · 2020: 9 · 2019: 4 · 2018: 9 · 2017: 1
FWCI
2.16
Type
journal article
Language
en
Open access
Licence
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universitätsbibliothek Erlangen-Nürnberg) (submittedVersion, cc-by)
Funders
  • Deutsche Forschungsgemeinschaft
  • Friedrich-Alexander-Universität Erlangen-Nürnberg
Topics
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
Keywords
tissue-engineered vascular grafts, polycaprolactone, type I collagen, electrospun nanofibers, biocompatibility, cell viability, extracellular matrix mimicry
MeSH terms
Animals, Bioprosthesis, Blood Vessel Prosthesis, Cell Line, Materials Testing, Polyesters, Tissue Engineering, Collagen Type I, Mice, Nanofibers

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