Markers and Biomarkers of Endothelium: When Something Is Rotten in the State
Open accessAbstract
Endothelium is a community of endothelial cells (ECs), which line the blood and lymphatic vessels, thus forming an interface between the tissues and the blood or lympha. This strategic position of endothelium infers its indispensable functional role in controlling vasoregulation, haemostasis, and inflammation. The state of endothelium is simultaneously the cause and effect of many diseases, and this is coupled with modifications of endothelial phenotype represented by markers and with biochemical profile of blood represented by biomarkers. In this paper, we briefly review data on the functional role of endothelium, give definitions of endothelial markers and biomarkers, touch on the methodological approaches for revealing biomarkers, present an implicit role of endothelium in some toxicological mechanistic studies, and survey the role of reactive oxygen species (ROS) in modulation of endothelial status.
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Both endothelial and HSEC lineages express endothelial biomarkers, including Kdr, Pecam1, Cd34, and Cdh5.
“While both endothelial and HSEC lineages express endothelial biomarkers, including Kdr, Pecam1, Cd34, and Cdh5”
From Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages (2020) · cites this paper as Goncharov et al., 2017
Section 2.1 identifies PECAM-1 as widely distributed on endothelium and discusses other endothelial markers, supporting the general marker description. The Introduction mentions liver sinusoidal endothelial cells, but the paper does not establish that both lineages express all four listed markers, including Kdr, Cd34, and Cdh5. No page numbers are available in our copy. (LLM, conf=0.82)
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References 268 · Cited by 190
Research works printed but not linked: 8
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- Authors
- Goncharov, N. V., Nadeev, A. D., Jenkins, R. O., & Avdonin, P. V.
- Affiliations
- Institute of Evolutionary Physiology and Biochemistry (RU)
- De Montfort University (GB)
- Koltzov Institute of Developmental Biology (RU)
- Corresponding author
- Goncharov, Nikolay V.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2017-01
- Volume
- 2017
- Issue
- 1
- Pages
- 9759735-9759735
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC5733214
- OpenAlex
- W2768631628
- Cited by
- 190
- References
- 268
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 21 · 2023: 29 · 2022: 39 · 2021: 25 · 2020: 31 · 2019: 14 · 2018: 3
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DMU Open Research Archive (De Montfort University) (submittedVersion)
- Funders
- Russian Science Foundation (16-15-00199)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- endothelium, endothelial cells, endothelial markers, endothelial dysfunction, reactive oxygen species, toxicology, vascular regulation, hemostasis, inflammation, endothelial phenotype
- MeSH terms
- Endothelium, Vascular, Humans, Peptidyl-Dipeptidase A, von Willebrand Factor, Biomarkers, Cell Adhesion Molecules, Cellular Senescence, Reactive Oxygen Species, Selectins, Receptors, Vascular Endothelial Growth Factor
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