Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases
Open accessAbstract
Vitamin A metabolite retinoic acid (RA) plays important roles in cell growth, differentiation, organogenesis, and reproduction and a key role in mucosal immune responses. RA promotes dendritic cells to express CD103 and to produce RA, enhances the differentiation of Foxp3 + inducible regulatory T cells, and induces gut-homing specificity in T cells. Although vitamin A is crucial for maintaining homeostasis at the intestinal barrier and equilibrating immunity and tolerance, including gut dysbiosis, retinoids perform a wide variety of functions in many settings, such as the central nervous system, skin aging, allergic airway diseases, cancer prevention and therapy, and metabolic diseases. The mechanism of RA is interesting to explore as both a mucosal adjuvant and a combination therapy with other effective agents. Here, we review the effect of RA on innate and adaptive immunity with a special emphasis on inflammatory status.
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Retinoids reduce transepidermal water loss by strengthening the epidermal barrier.
“Retinoids also reduce transepidermal water loss (TEWL) by strengthening the epidermal barrier [28,34,35].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [34]
Retinoids are responsible for the renewal of the epidermis through exfoliation of dead cells in the stratum corneum and proliferation of live cells in the epidermal layers.
“They are responsible for the renewal of the epidermis through their active role in the exfoliation of dead cells in the stratum corneum and the proliferation of live cells in the epidermal layers [28,34,35].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [34]
After penetrating the epidermis, retinoids play a role in the release of transcription and growth factors.
“After penetrating the epidermis, retinoids play a role in the release of transcription and growth factors.”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [34]
Vitamin A and all of its derivatives, applied systemically or topically, have a significant influence on skin health.
“Vitamin A and all of its derivatives, applied systemically or topically, have a significant influence on skin health.”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [34]
Retinoids inhibit cell division during excessive proliferation and activate it when the process is too slow.
“Retinoids are a group of chemical compounds that inhibit cell division during excessive proliferation and activate it when the process is too slow.”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [34]
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References 186 · Cited by 267
Research works printed but not linked: 1
- [5]WHO Guideline: Vitamin A Supplementation in Infants and Children 6–59 Months of Age 2011 Geneva World Health Organization 24575452
- Authors
- Oliveira, L. D. M., Teixeira, F. M. E., & Sato, M. N.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Sato, Maria Notomi
- Venue
- Mediators of Inflammation
- Publisher
- Wiley
- Published
- 2018-08-09
- Volume
- 2018
- Pages
- 1-17
- ISSN
- 0962-9351 (ISSN-L)
- 1466-1861
- PMC
- PMC6109577
- OpenAlex
- W2887837239
- Cited by
- 267
- References
- 186
- Citations by year
- 2026: 19 · 2025: 36 · 2024: 56 · 2023: 25 · 2022: 43 · 2021: 39 · 2020: 29 · 2019: 16 · 2018: 3
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Mediators of Inflammation (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Universidade de São Paulo
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- retinoic acid, vitamin A metabolites, immune cells, inflammatory diseases, dendritic cells, CD103, regulatory T cells, Foxp3, gut-homing T cells, mucosal immunity, intestinal barrier, gut dysbiosis, innate immunity, adaptive immunity, mucosal adjuvant, allergic airway disease, cancer therapy, metabolic disorders
- MeSH terms
- Animals, Dendritic Cells, Humans, Immunity, Innate, Macrophages, Models, Biological, Tretinoin, Adaptive Immunity
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