Age‐Dependent Protective Effect of Selenium against UVA Irradiation in Primary Human Keratinocytes and the Associated DNA Repair Signature
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Few studies have focused on the protective role of selenium (Se) against skin aging and photoaging even though selenoproteins are essential for keratinocyte function and skin development. To the best of our knowledge, the impact of Se supplementation on skin cells from elderly and young donors has not been reported. Therefore, the main objective of our study was to evaluate the effects of Se supplementation on skin keratinocytes at baseline and after exposure to ultraviolet A (UVA) irradiation. Low doses of Se (30 nM) were very potently protective against UVA‐induced cytotoxicity in young keratinocytes, whereas the protection efficiency of Se in old keratinocytes required higher concentrations (240 nM). Additionally, the DNA repair ability of the old keratinocytes drastically decreased compared with that of the young keratinocytes at baseline and after the UVA exposure. The Se supplementation significantly enhanced the DNA repair of 8‐oxoguanine (8oxoG) only in the keratinocytes isolated from young donors. Therefore, aged keratinocytes have an increased vulnerability to oxidative DNA damage, and the Se needs in the elderly should be considered. Strengthening DNA repair activities with Se supplementation may represent a new strategy to combat aging and skin photoaging.
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Low doses of selenium (30 nM) provide potent protection against UVA-induced cytotoxicity in young keratinocytes from 20-30-year-old donors, while higher concentrations (240 nM) are required for protective efficacy in old keratinocytes from donors 60-70 years old.
“Favrot et al. showed that low doses of Se (30 nM) provide potent protection against UVA-induced cytotoxicity in young keratinocytes (from 20–30-year-old donors), while higher concentrations (240 nM) were required for protective efficacy in old keratinocytes (from donors 60–70 years old) [92].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [92]
Selenium supplementation is an important strategy for inhibiting wrinkles because it can reverse ultraviolet light damage and play an anti-ageing role in the skin.
“Selenium supplementation is an important strategy for inhibiting wrinkles, because it can reverse ultraviolet light damage and play an anti-ageing role in the skin [89,92].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [92]
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References 50 · Cited by 36
- Authors
- Favrot, C., Beal, D., Blouin, E., Leccia, M. T., Roussel, A. M., & Rachidi, W.
- Affiliations
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- LABCATAL (France) (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Université Grenoble Alpes (FR)
- Corresponding author
- Rachidi, W.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2018-01
- Volume
- 2018
- Issue
- 1
- Pages
- 5895439-5895439
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC5842700
- OpenAlex
- W2789893715
- Cited by
- 36
- References
- 50
- Citations by year
- 2025: 3 · 2023: 3 · 2022: 6 · 2021: 9 · 2020: 5 · 2019: 8 · 2018: 1 · 2017: 1
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Labcatal Pharmaceuticals
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Organoselenium and organotellurium chemistry
- Keywords
- selenium supplementation, UVA irradiation, keratinocytes, photoaging, skin aging, DNA repair, oxidative DNA damage, 8-oxoguanine, selenoproteins, cytotoxicity, older adults
- MeSH terms
- Adult, Age Factors, Aged, Cells, Cultured, DNA Repair, Humans, Middle Aged, Selenium, Ultraviolet Rays, Keratinocytes, Young Adult
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