Helicobacter pylori Infection and Gastric Dysbiosis: Can Probiotics Administration Be Useful to Treat This Condition?
Open accessAbstract
Helicobacter pylori (Hp) is responsible for one of the most common infections in the world. The prevalence exceeds 50% of the population in developing countries, and approximately one-third of the adults are colonized in North Europe and North America. It is considered a major pathogenic agent of chronic gastritis, peptic ulcer, atrophic gastritis, gastric cancer, and mucosa-associated lymphoid tissue lymphoma (MALT). Hp colonization modifies the composition of gastric microbiota that could drive the development of gastric disorders. Currently, an emerging problem in Hp treatment is represented by the increasing rate of antimicrobial therapy resistance. In this context, the search for adjuvant agents can be very useful to overcome this issue and probiotics administration can represent a valid option. The aim of this review is to describe the gastric microbiota changes during Hp colonization, the mechanisms of action, and a possible role of probiotics in the treatment of this infection.
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During H. pylori infection, the gastric microbiota is predominantly constituted of Proteobacteria, followed by Firmicutes, Bacteroidetes and Actinobacteria.
“During the infection, the gastric microbiota is predominantly constituted of Proteobacteria, followed by Firmicutes, Bacteroidetes and Actinobacteria[54].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [54]
The gastric microbiota is composed mainly of Firmicutes, Bacteroidetes, Proteobacteria and Actinobacteria, with the most abundant genera being Streptococcus, followed by Veillonella, Prevotella, Fusobacterium and Rothia.
“The gastric microbiota is composed mainly of Firmicutes, Bacteroidetes, Proteo-bacteria and Actinobacteria, with the most abundant genera being Streptococcus, followed by Veillonella, Prevotella, Fusobacterium and Rothia[54].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [54]
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References 64 · Cited by 32
- Authors
- Bruno, G., Rocco, G., Zaccari, P., Porowska, B., Mascellino, M. T., & Severi, C.
- Affiliations
- Sapienza University of Rome (IT)
- Corresponding author
- Bruno, Giovanni
- Venue
- Canadian Journal of Infectious Diseases and Medical Microbiology
- Publisher
- Wiley
- Published
- 2018-09-10
- Volume
- 2018
- Pages
- 1-7
- ISSN
- 1180-2332 (ISSN-L)
- 1712-9532
- 1918-1493
- PMC
- PMC6151681
- OpenAlex
- W2892234433
- Cited by
- 32
- References
- 64
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 2 · 2020: 4 · 2019: 8
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Canadian Journal of Infectious Diseases and Medical Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Helicobacter pylori infection, gastric microbiota, probiotics, chronic gastritis, peptic ulcer, atrophic gastritis, gastric cancer, MALT lymphoma, antimicrobial resistance, adjuvant therapy
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