A randomised, controlled study of different glycaemic targets during gestational diabetes treatment: effect on the level of adipokines in cord blood and ANGPTL4 expression in human umbilical vein endothelial cells
Open accessAbstract
Our aim was to study the expression of adipokine-encoding genes (leptin, adiponectin, and angiopoietin-like protein 4 (ANGPTL4)) in human umbilical vein endothelial cells (HUVECs) and adipokine concentration in cord blood from women with gestational diabetes mellitus (GDM) depending on glycaemic targets. GDM patients were randomised to 2 groups per target glycaemic levels: GDM1 (tight glycaemic targets, fasting blood glucose < 5.1 mmol/L and <7.0 mmol/L postprandial, N=20 ) and GDM2 (less tight glycaemic targets, <5.3 mmol/L and < 7.8 mmol/L, respectively, N=21 ). The control group included 25 women with normal glucose tolerance. ANGPTL4 expression was decreased in the HUVECs from GDM patients versus the control group (23.11 ± 5.71, 21.47 ± 5.64, and 98.33 ± 20.92, for GDM1, GDM2, and controls; p<0.001 ) with no difference between GDM1 and GDM2. The level of adiponectin gene expression was low and did not differ among the groups. Leptin gene expression was undetectable in HUVECs. In cord blood, leptin/adiponectin ratio (LAR) was increased in GDM2 compared to controls and GDM1 ( p=0.038 ) and did not differ between GDM1 and controls. Tight glycaemic targets were associated with normalisation of increased LAR in the cord blood. ANGPTL4 expression was downregulated in HUVECs of newborns from GDM mothers and was not affected by the intensity of glycaemic control.
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ANGPTL proteins are secreted by adipose tissue, skeletal muscle, intestinal, and liver cells and are responsible for energy metabolism, TG turnover modulation in adipose tissue, and regulation of blood glucose levels.
“Angiopoietin-like protein (ANGPTL) is a group of proteins that can be secreted by the AT, SkM, intestinal, and liver cells and is responsible for several processes, among them energy metabolism, and TG turnover modulation in AT and the regulation of blood glucose levels (Ingerslev et al., 2017; Popova et al., 2018).”
From Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases (2018) · cites this paper as Popova et al., 2018
The Introduction (page not provided) describes ANGPTL4 as expressed in many tissues and involved in energy metabolism, plasma glucose regulation, fat storage, and lipid metabolism. It does not extend those functions to ANGPTL proteins as a group or specify secretion by skeletal muscle and intestinal cells or triglyceride turnover in adipose tissue. The Discussion (page not provided) mentions the liver only as a plausible source of cord-serum ANGPTL4. (LLM, conf=0.86)
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References 43 · Cited by 27
- Authors
- Popova, P., Vasilyeva, L., Tkachuck, A., Puzanov, M., Golovkin, A., Bolotko, Y., Pustozerov, E., Vasilyeva, E., Li, O., Zazerskaya, I., Dmitrieva, R., Kostareva, A., & Grineva, E.
- Affiliations
- First Pavlov State Medical University of St. Petersburg (RU)
- Federal Almazov North-West Medical Research Centre (RU)
- Almazov National Medical Research Centre, Saint Petersburg, Russia
- Corresponding author
- Popova, P.
- ORCID
- Venue
- International Journal of Endocrinology
- Publisher
- Wiley
- Published
- 2018
- Volume
- 2018
- Pages
- 1-8
- ISSN
- 1687-8337 (ISSN-L)
- 1687-8345
- PMC
- PMC5976949
- OpenAlex
- W2803459701
- Cited by
- 27
- References
- 43
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 7 · 2018: 1
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Endocrinology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Russian Science Foundation (17-75-30052)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- gestational diabetes mellitus, glycemic targets, tight glycemic control, adipokines, leptin, adiponectin, ANGPTL4, umbilical cord blood, human umbilical vein endothelial cells, leptin/adiponectin ratio, endothelial gene expression
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