The DOI matches its Crossref record.
Antitumor Effect of Albendazole on Cutaneous Squamous Cell Carcinoma (SCC) Cells
Open accessAbstract
Drug repurposing and/or repositioning is an alternative method to develop new treatment for certain diseases. Albendazole was originally developed as an anthelmintic medication, and it has been used to treat a variety of parasitic infestations. In this study, we investigated the antitumor effect of albendazole and putative action mechanism. Results showed that albendazole dramatically decreased the cell viability of SCC cell lines (SCC12 and SCC13 cells). Albendazole increased apoptosis-related signals, including cleaved caspase-3 and PARP-1 in a dose-dependent fashion. The mechanistic study showed that albendazole induced endoplasmic reticulum (ER) stress, evidenced by increase of CHOP, ATF-4, caspase-4, and caspase-12. Pretreatment with ER stress inhibitor 4-PBA attenuated albendazole-induced apoptosis of SCC cells. In addition, albendazole decreased the colony-forming ability of SCC cells, together with inhibition of Wnt/β-catenin signaling. These results indicate that albendazole shows an antitumor effect via regulation of ER stress and cancer stemness, suggesting that albendazole could be repositioned for cutaneous SCC treatment.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Albendazole also showed anti-tumor effects on cutaneous squamous cell carcinoma cells via regulation of endoplasmic reticulum stress and cancer stemness.
“Albendazole also showed anti-tumor effects on cutaneous squamous cell carcinoma cells via regulation of endoplasmic reticulum stress and cancer stemness [356].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [356]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 29
- 10.1111/ijd.12553 · DOI
- 10.1016/j.jphotobiol.2016.08.022 · DOI
- 10.1016/j.jaad.2013.09.026 · DOI
- 2012, American Family Physician, 86, 161
- 2016, Scientific Reports, 6
- 10.5021/ad.2018.30.1.119 · DOI
- 10.1111/j.1365-2133.2006.07232.x · DOI
- 2014, Journal of Drugs in Dermatology, 13, 1413
- 10.1128/CMR.14.1.150-164.2001 · DOI
- 10.1016/j.ijantimicag.2014.01.013 · DOI
- 10.1007/s11010-016-2927-3 · DOI
- 2011, Journal of Radiation Oncology, 6
- 10.1016/j.bcp.2018.11.003 · DOI
- 1981, Cancer Research, 41, 1657
- 10.1016/j.jdermsci.2008.11.006 · DOI
- 10.1016/j.bbamcr.2013.06.028 · DOI · Paper page
- 10.1083/jcb.200310015 · DOI
- 10.1152/ajprenal.00225.2016 · DOI
- 10.1038/nature06835 · DOI
- 10.1091/mbc.11.10.3509 · DOI
- 10.3892/etm.2016.3992 · DOI
- 10.2174/1568009615666141229152812 · DOI
- 10.1038/nrneph.2017.129 · DOI
- 10.1038/ncb3184 · DOI
- 10.1093/jb/mvr143 · DOI
- 10.1016/j.cellsig.2012.05.006 · DOI
- 10.1083/jcb.201612165 · DOI · Paper page
- 10.1517/14728222.2014.906580 · DOI
- 10.1016/j.yexcr.2018.03.033 · DOI
Cited by
Sorted by citations
Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286
Repurposing of Benzimidazole Anthelmintic Drugs as Cancer Therapeutics
Song, B., Park, E. Y., Kim, K. J., & Ki, S. H. (2022) · Cancers · doi:10.3390/cancers14194601 · Cited by 55
Metadata
- Authors
- Zhang, Q.-L., Lian, D.-D., Zhu, M. J., Li, X. M., Lee, J. K., Yoon, T.-J., Lee, J.-H., Jiang, R.-H., & Kim, C. D.
- Affiliations
- Department of Dermatology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China
- Department of Intensive Care Unit, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China
- Jilin University (CN)
- Chungnam National University (KR)
- Gyeongsang National University (KR)
- Corresponding author
- Kim, Chang Deok
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2019-06-09
- Volume
- 2019
- Pages
- 1-9
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC6590486
- OpenAlex
- W2948130613
- Cited by
- 26
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 2
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Research Foundation of Korea (NRF-2017R1A2B4008810, 20170414056GH)
- Technological Development Plan Project in Jilin Province (NRF-2017R1A2B4008810, 20170414056GH)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- albendazole, cutaneous squamous cell carcinoma, drug repurposing, endoplasmic reticulum stress, apoptosis, Wnt/β-catenin signaling, cancer stemness, CHOP, 4-phenylbutyric acid, caspase-3, PARP1, anticancer activity
- MeSH terms
- Antineoplastic Agents, Carcinoma, Squamous Cell, Humans, Skin Neoplasms, Neoplastic Stem Cells, Tunicamycin, Keratinocytes, Albendazole, Apoptosis, Cell Line, Tumor, Endoplasmic Reticulum Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
