The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Current Challenges in Cancer Immunotherapy: Multimodal Approaches to Improve Efficacy and Patient Response Rates
Open accessAbstract
Cancer immunotherapy is a promising innovative treatment for many forms of cancer, particularly melanoma. Although immunotherapy has been shown to be efficacious, patient response rates vary and, more often than not, only a small subset of the patients within a large cohort respond favourably to the treatment. This issue is particularly concerning and becomes a challenge of immunotherapy to improve the effectiveness and patient response rates. Here, we review the specific types of available immunotherapy options, their proposed mechanism(s) of action, and the reasons why the patient response to this treatment is variable. The potential favourable options to improve response rates to immunotherapy will be discussed with an emphasis on adopting a multimodal approach on the novel role that the gut microbiota may play in modulating the efficacy of cancer immunotherapy.
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Cites
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
Routy, B., Le Chatelier, E., Derosa, L., Duong, C. P. M., Alou, M. T., Daillère, R., Fluckiger, A., Messaoudene, M., Rauber, C., Roberti, M. P., et al. (2018) · Science · doi:10.1126/science.aan3706 · Cited by 5,671
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Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients
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“Additionally, cancer patients that responded to immunotherapy had an increase in antitumor killer T cells and the difference in killer T cell quantity was correlated to the presence of species within the Faecalibacterium and Clostridiales phyla [13].”
BackgroundNeoantigens in cancer immunotherapy
Schumacher, T. N., & Schreiber, R. D. (2015) · Science · doi:10.1126/science.aaa4971 · Cited by 4,783
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
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“[34] demonstrated that the rate of tumor growth decreased through oral administration of the Bifidobacteria alone or in combination with anti-PD-L1 immunotherapy in mouse models of melanoma.”
BackgroundAnticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
Vétizou, M., Pitt, J. M., Daillère, R., Lepage, P., Waldschmitt, N., Flament, C., Rusakiewicz, S., Routy, B., Roberti, M. P., Duong, C. P. M., et al. (2015) · Science · doi:10.1126/science.aad1329 · Cited by 3,488 · cited 1×
“[33] demonstrated a correlation between the effectiveness of cancer immunotherapies and the composition of the gut microbiome, thereby implicating a more involved role for probiotics.”
BackgroundMutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
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Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment
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Cited by
Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer
Law, A. M. K., Valdes-Mora, F., & Gallego-Ortega, D. (2020) · Cells · doi:10.3390/cells9030561 · Cited by 455
Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies
Shankar, K., Capitini, C. M., & Saha, K. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01741-4 · Cited by 85
Metadata
- Authors
- Sambi, M., Bagheri, L., & Szewczuk, M. R.
- Venue
- Journal of Oncology
- Publisher
- Wiley
- Published
- 2019-02-28
- Volume
- 2019
- Pages
- 1-12
- ISSN
- 1687-8450 (ISSN-L)
- 1687-8469
- OpenAlex
- W2918589641
- Cited by
- 313
- References
- 60
- FWCI
- 15.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sambi, M., Bagheri, L., & Szewczuk, M. R. (2019). Current Challenges in Cancer Immunotherapy: Multimodal Approaches to Improve Efficacy and Patient Response Rates. Journal of Oncology. https://doi.org/10.1155/2019/4508794
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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