Clinical and Biological Correlates of Preoperative Cognitive Functioning of Glioma and Meningioma Patients
Open accessAbstract
Objectives. This study aimed to investigate the association of high‐sensitivity C‐reactive protein (hsCRP) and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) serum concentrations with cognitive functions of glioma and meningioma patients. Methods. 177 brain tumor patients awaiting for brain tumor surgery participated in the study. Patients were assessed preoperatively, using neuropsychological tests for verbal memory, psychomotor speed, mental flexibility, and verbal fluency. The functional status of patients was evaluated using the Karnofsky Performance Index. Blood samples were drawn for evaluation of serum hsCRP and NT‐proBNP concentrations upon hospital admission. Results. The highest NT‐proBNP concentration was observed in meningioma patients. Glioma and meningioma patients did not differ in hsCRB concentration. Patients in the highest hsCRP tertile were older and more frequently reported cardiovascular comorbidity. Patients in the highest NT‐proBNP tertile were older, more frequently with cardiovascular comorbidity, females, and diagnosed with a meningioma. hsCRP was significantly related to slower psychomotor speed in high‐grade glioma patients (rho = 0.30, p < 0.05). In meningioma sample, NT‐proBNP correlated with decreased psychomotor speed (rho = 0.38, p < 0.01), mental flexibility (rho = 0.33, p < 0.01), worse cumulative learning (rho = −0.27, p < 0.05), and delayed recall (rho = 0.30, p < 0.01). However, the relationship between the NT‐proBNP and cognitive functions became nonsignificant when demographic and clinical covariates were included into analysis. Higher hsCRP concentration remained significantly related to slower psychomotor speed (p = 0.02) and worse mental flexibility (p = 0.05) in glioma patients, independently from demographic and clinical covariates. Preoperative cognitive functioning was also predicted by older age, gender, side and location of the tumor, and tumor malignancy, and general functional status of a patient. Conclusions. NT‐proBNP was not associated with memory, language, and attention/executive cognitive domains of glioma and meningioma patients. Increased hsCRP was related to slower psychomotor speed and worse mental flexibility in glioma patients, indicating that inflammation processes are important for cognitive functioning in glial tumors.
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CRP blood levels have been associated with reduced performance in the Trail Making Test in several patient groups experiencing ongoing peripheral inflammatory activity.
“Furthermore, CRP blood levels have been associated with reduced performance in the TMT in several patient groups experiencing ongoing peripheral inflammatory activity, such as those with peripheral arterial disease [49] and brain cancer [50] and aging populations [51].”
From Baseline Pro-Inflammatory Cytokine Levels Moderate Psychological Inflexibility in Behavioral Treatment for Chronic Pain (2022) · cites this paper as [50]
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References 55 · Cited by 11
Research works printed but not linked: 1
- [33]Strauss E. Sherman E. M. S. Spreen O. A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary 2006 3rd New York Oxford University Press
- Authors
- Pranckeviciene, A., Deltuva, V. P., Tamasauskas, A., Zegliene, J., & Bunevicius, A.
- Affiliations
- Lithuanian University of Health Sciences (LT)
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2020-01
- Volume
- 2020
- Issue
- 1
- Pages
- 2054859-2054859
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC7232682
- OpenAlex
- W3022116819
- Cited by
- 11
- References
- 55
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 1
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Lithuanian University of Health Sciences (submittedVersion)
- Funders
- Lietuvos Mokslo Taryba (MIP-044/2015)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- meningioma, preoperative cognitive function, high-sensitivity C-reactive protein, NT-proBNP, psychomotor speed, cognitive flexibility, verbal memory, inflammation, brain tumor surgery, cardiovascular comorbidity, neuropsychological assessment, executive function, delayed recall, verbal fluency
- MeSH terms
- Adult, Aged, Brain Neoplasms, C-Reactive Protein, Cognition, Female, Glioma, Humans, Male, Memory, Meningioma, Middle Aged, Neuropsychological Tests, Peptide Fragments, Biomarkers, Natriuretic Peptide, Brain
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