The intricate relationship between type 2 diabetes mellitus (T2DM), insulin resistance (IR), and nonalcoholic fatty liver disease (NAFLD)
Open accessAbstract
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) remain as one of the most global problematic metabolic diseases with rapidly increasing prevalence and incidence. Epidemiological studies noted that T2DM patients have by two-fold increase to develop NAFLD, and vice versa. This complex and intricate association is supported and mediated by insulin resistance (IR). In this review, we discuss the NAFLD immunopathogenesis, connection with IR and T2DM, the role of screening and noninvasive tools, and mostly the impact of the current antidiabetic drugs on steatosis liver and new potential therapeutic targets.
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In the same systematic review, the traditional Mediterranean diet was the most efficacious dietary pattern in improving postprandial hyperglycaemia and insulin sensitivity at equivalent body weight.
“the traditional Mediterranean diet emerged as the most efficacious in improving postprandial hyperglycaemia and insulin sensitivity at an equivalent body weight.”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [95]
Omega-3 PUFAs, specifically EPA and DHA, have antioxidant and anti-inflammatory properties.
“omega-3 PUFAs, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are renowned for their antioxidant and anti-inflammatory properties (95–97).”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [95]
In a systematic review by Tanase et al., all nine dietary patterns compared induced a significant reduction in Hb1Ac levels after 12 weeks.
“the review revealed that, while all dietary patterns induced a significant reduction in Hb1Ac levels after 12 weeks”
From Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility (2024) · cites this paper as [95]
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References 217 · Cited by 627
Research works printed but not linked: 1
- [23]International Diabetes Federation IDF DIABETES ATLAS -9TH EDITION April 2020, http://www.diabetesatlas.org 35914061
- Authors
- Tanase, D. M., Gosav, E. M., Costea, C. F., Ciocoiu, M., Lacatusu, C. M., Maranduca, M. A., Ouatu, A., & Floria, M.
- Affiliations
- Department of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania
- Grigore T. Popa University of Medicine and Pharmacy (RO)
- Unit of Diabetes, Nutrition and Metabolic Diseases, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania
- Department of Physiology, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania
- Corresponding author
- Gosav, Evelina Maria
- ORCID
- Venue
- Journal of Diabetes Research
- Publisher
- Wiley
- Published
- 2020-08-04
- Volume
- 2020
- Pages
- 1-16
- ISSN
- 2314-6745 (ISSN-L)
- 2314-6753
- PMC
- PMC7424491
- OpenAlex
- W3047056909
- Cited by
- 627
- References
- 217
- Citations by year
- 2026: 74 · 2025: 187 · 2024: 161 · 2023: 113 · 2022: 62 · 2021: 25 · 2020: 5
- FWCI
- 7.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Diabetes Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- type 2 diabetes, insulin resistance, non-alcoholic fatty liver disease, NAFLD screening, antidiabetic drugs, hepatic steatosis, therapeutic target
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Insulin Resistance, Liver, Signal Transduction, Non-alcoholic Fatty Liver Disease
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