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Cited by 15Electrospun Nanofibers in Biomedical ApplicationsIntestinal and Peritoneal AdhesionsSurgical Sutures and Adhesives

Prevention of Postsurgical Abdominal Adhesion Using Electrospun TPU Nanofibers in Rat Model

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Gholami, Ahmad, Abdoluosefi, Homeira Emad, Riazimontazer, Elham, Azarpira, Negar, Behnam, Mohamadali, Emami, Farzin, Omidifar, Navid·2021·BioMed Research International
DOI 10.1155/2021/9977142PMC PMC8727164
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Abstract

Intra‐abdominal adhesions following surgery are a challenging problem in surgical practice. This study fabricated different thermoplastic polyurethane (TPU) nanofibers with different average diameters using the electrospinning method. The conditions were evaluated by scanning electron microscopy (SEM), atomic force microscope (AFM), and Fourier transform infrared spectrometer (FTIR) analysis. A static tensile test was applied using a strength testing device to assess the mechanical properties of the electrospun scaffolds. By changing the effective electrospinning parameters, the best quality of nanofibers could be achieved with the lowest bead numbers. The electrospun nanofibers were evaluated in vivo using a rat cecal abrasion model. The macroscopic evaluation and the microscopic study, including the degree of adhesion and inflammation, were investigated after three and five weeks. The resultant electrospun TPU nanofibers had diameters ranging from about 200 to 1000 nm. The diameters and morphology of the nanofibers were significantly affected by the concentration of polymer. Uniform TPU nanofibers without beads could be prepared by electrospinning through reasonable control of the process concentration. These nanofibers’ biodegradability and antibacterial properties were investigated by weight loss measurement and microdilution methods, respectively. The purpose of this study was to provide electrospun nanofibers having biodegradability and antibacterial properties that prevent any adhesions or inflammation after pelvic and abdominal surgeries. The in vivo experiments revealed that electrospun TPU nanofibers reduced the degree of abdominal adhesions. The histopathological study confirmed only a small extent of inflammatory cell infiltration in the 8% and 10% TPU. Conclusively, nanofibers containing 8% TPU significantly decreased the incidence and severity of postsurgical adhesions, and it is expected to be used in clinical applications in the future.

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  • Electrospun thermoplastic polyurethane nanofiber meshes significantly reduced post-surgical adhesion formation in a rat abdominal adhesion model, with treated animals showing much lower adhesion scores and minimal inflammation.

    “For example, electrospun thermoplastic polyurethane (TPU) nanofiber meshes significantly reduced post-surgical adhesion formation in a rat abdominal adhesion model, with treated animals showing much lower adhesion scores and minimal inflammation [272].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [272]

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Authors
Gholami, A., Abdoluosefi, H. E., Riazimontazer, E., Azarpira, N., Behnam, M., Emami, F., & Omidifar, N.
Affiliations
  • Shiraz University (IR)
  • University of Kashan (IR)
  • Shiraz University of Medical Sciences (IR)
  • Shiraz University of Technology (IR)
Corresponding author
  • Riazimontazer, Elham
  • Azarpira, Negar
ORCID
Venue
BioMed Research International
Publisher
Wiley
Published
2021-01
Volume
2021
Issue
1
Pages
9977142-9977142
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
DOI
10.1155/2021/9977142
PMC
PMC8727164
OpenAlex
W4200001426
Cited by
15
References
0
Citations by year
2026: 1 · 2025: 7 · 2024: 2 · 2023: 5
FWCI
0.45
Type
journal article
Language
en
Open access
Licence
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Shiraz University of Medical Sciences (20258)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
Keywords
electrospun nanofibers, thermoplastic polyurethane, adhesion prevention, electrospinning parameters, nanofiber diameter, mechanical properties, biodegradability, antibacterial properties, inflammation
MeSH terms
Tissue Adhesions, Animals, Female, Inflammation, Microscopy, Electron, Scanning, Polymers, Polyurethanes, Postoperative Complications, Rats, Sprague-Dawley, Models, Animal, Tissue Engineering, Abdominal Wall, Rats, Nanofibers

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