An Overview of Hormone-Sensitive Lipase (HSL)
Open accessAbstract
Hormone-sensitive lipase (HSL) is a pivotal enzyme that mediates triglyceride hydrolysis to provide free fatty acids and glycerol in adipocytes in a hormonally controlled lipolysis process. Elevated plasma-free fatty acids were accompanied by insulin resistance, type-2 diabetes, and obesity. Inhibition of lipolysis through HSL inhibition may provide a mechanism to prevent the accumulation of free fatty acids and to improve the affectability of insulin and blood glucose handling in type II diabetes. The published studies that examine the structure, regulation, and function of HSL and major inhibitors were reviewed in this paper.
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Hormone-sensitive lipase activity increases in adipose tissue under caloric restriction as insulin levels decline, and glucagon and catecholamines stimulate HSL through β-adrenergic receptors, promoting lipolysis and releasing free fatty acids and glycerol.
“Hormone-sensitive lipase (HSL) activity increases in adipose tissue under caloric restriction as insulin levels decline. Glucagon and catecholamines stimulate HSL through β-adrenergic receptors, promoting lipolysis and releasing free fatty acids (FFAs) and glycerol into circulation.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [35]
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References 94 · Cited by 129
Research works printed but not linked: 1
- [45]Zechner R. Zimmermann R. Eichmann T. O. FAT SIGNALS-lipases and lipolysis in lipid metabolism and signaling Cell Metabolism 2012 15 3 279 291 10.1016/j.cmet.2011.12.018 2-s2.0-84858020291 22405066 PMC3314979 · DOI
- Authors
- Althaher, A. R.
- Affiliations
- Al-Zaytoonah University of Jordan (JO)
- Corresponding author
- Althaher, Arwa R.
- ORCID
- Althaher, Arwa R.
- Venue
- The Scientific World Journal
- Publisher
- Wiley
- Published
- 2022-12-08
- Volume
- 2022
- Pages
- 1-9
- ISSN
- 1537-744X (ISSN-L)
- 2356-6140
- PMC
- PMC9754850
- OpenAlex
- W4311937385
- Cited by
- 129
- References
- 94
- Citations by year
- 2026: 28 · 2025: 44 · 2024: 43 · 2023: 14
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- The Scientific World JOURNAL (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- hormone-sensitive lipase, lipolysis, adipocytes, free fatty acids, insulin resistance, type 2 diabetes, obesity
- MeSH terms
- Sterol Esterase, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Humans, Lipase, Lipolysis
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