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Cited by 7Ferroptosis and cancer prognosisCancer-related molecular mechanisms researchCancer Immunotherapy and Biomarkers

A Pancancer Study of PIEZO1 as a Prognosis and Immune Biomarker of Human Tumors

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Wu, Yunhui, Zhang, Jingying, Hou, Can, Wang, Hongyu, Zhu, Min, Yao, Xin·2022·Journal of Oncology
DOI 10.1155/2022/6725570PMC PMC9213189
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Abstract

PIEZO1, a mechanosensitive ion channel protein, has been identified in the correlation between several cancers. However, the systematic pancancer study of PIEZO1 still lacks. We examined PIEZO1 across thirty-three types of cancers to explore its role in prognosis and immunological function for the first time. Based on the open databases TCGA, GTEx and CPTAC, PIEZO1 has been demonstrated to be differentially expressed in most cancers compared to adjacent normal tissues. The distinct correlation between PIEZO1 and prognosis of tumor patients was explored by GEPIA2. Genetic alteration of PIEZO1 in the TCGA tumors showed that mutation is the alteration which is linked to OS, DSS, DFS and PFS in some tumors. Alterations of protein phosphorylation levels were detected in some cancers based on the CPTAC dataset. PIEZO1 expression was linked with immune cell infiltration, such as endothelial cell and cancer-associated fibroblast. Finally, KEGG and GO enrichment analyses were applied to investigate the molecular mechanism of PIEZO1. Our first pancancer analysis illustrated the roles of PIEZO1 in different types of tumors.

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  • Biomarker-based patient stratification using Piezo1 expression levels or mutation profiles may enhance treatment outcomes, particularly since expression levels vary across tissues and disease states.

    “Biomarker-based patient stratification using Piezo1 expression levels or mutation profiles may enhance treatment outcomes, particularly since expression levels vary across tissues and disease states.146”

    From Mechanosensitive calcium ion channels Piezo1: A therapeutic target in liver disease (2025) · cites this paper as [146]

    The Results (§3.1; page unavailable) show that PIEZO1 expression differs across tumor types and pathological stages. The Discussion (§4; page unavailable) links expression and genetic alterations to prognosis and suggests relevance to cancer immunotherapy. It does not show that stratifying patients by PIEZO1 expression or mutation profile improves treatment outcomes. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Wu, Y., Zhang, J., Hou, C., Wang, H., Zhu, M., & Yao, X.
Affiliations
Jiangsu Province Hospital (CN)
Corresponding author
Yao, Xin
ORCID
Venue
Journal of Oncology
Publisher
Wiley
Published
2022-06-14
Volume
2022
Pages
1-15
ISSN
  • 1687-8450 (ISSN-L)
  • 1687-8469
DOI
10.1155/2022/6725570
PMC
PMC9213189
OpenAlex
W4282915895
Cited by
7
References
2
Citations by year
2025: 4 · 2024: 2 · 2022: 1
FWCI
1.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Oncology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Nanjing Medical University (81870039, 82170040)
  • National Natural Science Foundation of China (81870039, 82170040)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords
Piezo1, mechanosensitive ion channels, pan-cancer analysis, prognostic factors, tumor immune infiltration, immune cell infiltration, cancer-associated fibroblasts, endothelial cells, gene expression, genetic alterations, protein phosphorylation, overall survival, differential survival

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