The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Chronic Appendicitis: Possible Differential Diagnosis in Patients with Chronic Abdominal Pain
Open accessAbstract
In the emergency department, patients frequently present with abdominal pain, with a variety of different causes ranging from intra‐abdominal to extra‐abdominal and retroperitoneal pathologies which can affect all age groups. Chronic appendicitis is a rare medical condition characterized by less severe and continuous abdominal pain and a clinical picture lasting longer than 1‐2 days and extending over months, even years, and it is not always possible to consider it as a preliminary diagnosis. We represent a case report of chronic appendicitis where the patient’s clinical picture led the diagnostics and treatment in different directions and delayed the diagnosis. Namely, our patient was radiologically diagnosed with a collection of denser content retroperitoneally in the right lower quadrant of the abdomen, which in the first place was not related to possible appendicitis, regarding complaints. The existence of chronic appendicitis is a diagnosis unfamiliar to many clinicians and has no official diagnostic criteria. After diagnosis, treatment usually begins with antibiotics, and the next most common step is surgery. The optimal treatment for this condition is unknown. With this case report, we wish to draw attention to chronic appendicitis as a possible differential diagnosis in patients with chronic abdominal pain.
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“Chronic appendicitis is a rare and often debated clinical entity characterized by prolonged or recurrent inflammation of the appendix, typically presenting with vague, intermittent right lower quadrant abdominal pain and sometimes accompanied by mild gastrointestinal symptoms such as nausea, bloating, or changes in bowel habits.”
From Selective Appendectomy in Patients Undergoing Minimally Invasive Surgery for Endometriosis: A Retrospective Cohort Study (2025) · cites this paper as [10]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Importantly, these conditions can coexist, further complicating clinical interpretation and emphasizing the need for careful intraoperative evaluation [8,10].”
From Selective Appendectomy in Patients Undergoing Minimally Invasive Surgery for Endometriosis: A Retrospective Cohort Study (2025) · cites this paper as [10]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Endometriosis involving the appendix or adjacent pelvic structures can mimic chronic appendicitis by causing localized inflammation, adhesions, or fibrosis.”
From Selective Appendectomy in Patients Undergoing Minimally Invasive Surgery for Endometriosis: A Retrospective Cohort Study (2025) · cites this paper as [10]
Experimental — accuracy not yet measured
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Citations
Cites
Treatment of acute abdominal pain in the emergency room: A systematic review of the literature
Falch, C., Vicente, D. A., Haeberle, H. A., Kirschniak, A., Muller, S., Nissan, A., & Brücher, B. L. D. M. (2014) · European Journal of Pain · doi:10.1002/j.1532-2149.2014.00456.x · Cited by 76
Su, D., Li, Q., Zhang, T., Veliz, P. T., Chen, Y., He, K., Mahajan, P., & Zhang, X. (2022) · BMC Medical Research Methodology · doi:10.1186/s12874-021-01490-9 · Cited by 26
Chronic Appendicitis, the Lesser-Known Form of Appendiceal Inflammation: A Case Report
Lee, C. K., Pelenyi, S. S., Fleites, O., et al. (2021) · Cureus · doi:10.7759/cureus.19718 · Cited by 19
Chronic appendicitis: two case reports
Holm, N., Rømer, M. U., Markova, E., et al. (2022) · Journal of Medical Case Reports · doi:10.1186/s13256-022-03273-2 · Cited by 16
Chronic appendicitis: the process from pre-diagnosis to pathology.
Kanat, B. H., Solmaz, Ö. A., Bozdağ, P. G., et al. (2021) · PubMed · doi:10.26355/eurrev_202112_27639 · Cited by 10
Vom Leitsymptom zur Diagnose: abdominelle Beschwerden
Michael, M., Kleophas, A., Keitel, V., et al. (2021) · AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie · doi:10.1055/a-1191-1374 · Cited by 9
A 61-Year-Old Male With Chronic Appendicitis: A Case Report
Almansouri, O. S., Algethmi, A. M., Qutub, M., et al. (2022) · Cureus · doi:10.7759/cureus.32130 · Cited by 8
Cited by
Sorted by citations
Nezhat, C., Najmi, Z., Mirzaie, M., Harding, Q., Pennington, Z., Amirlatifi, N., Khaloghli, R., Zarroug, D., & Sokol, E. R. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14207277 · Cited by 1
“Importantly, these conditions can coexist, further complicating clinical interpretation and emphasizing the need for careful intraoperative evaluation [8,10].”
Influential
Metadata
- Authors
- Ljubas, I., Jurca, I., & Grgić, D.
- Affiliations
- University Hospital Centre Zagreb (HR)
- Corresponding author
- Grgić, Dora
- Venue
- Case Reports in Surgery
- Publisher
- Wiley
- Published
- 2024-01
- Volume
- 2024
- Issue
- 1
- Pages
- 6032042-6032042
- ISSN
- 2090-6900 (ISSN-L)
- 2090-6919
- PMC
- PMC10791266
- OpenAlex
- W4390734413
- Cited by
- 5
- References
- 7
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Case Reports in Surgery (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Emergency Medicine › Appendicitis Diagnosis and Management
- Health Sciences › Medicine › Surgery › Omental and Epiploic Conditions
- Health Sciences › Medicine › Surgery › Gastrointestinal disorders and treatments
- Keywords
- chronic appendicitis, chronic abdominal pain, differential diagnosis, retroperitoneal mass, delayed diagnosis, right lower quadrant, antibiotic therapy, surgical treatment
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- CoChat. (2026). Citation check: Chronic Appendicitis: Possible Differential Diagnosis in Patients with Chronic Abdominal Pain. https://app.cochat.ai/papers/10.1155/2024/6032042
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- Ljubas, I., Jurca, I., & Grgić, D. (2024). Chronic Appendicitis: Possible Differential Diagnosis in Patients with Chronic Abdominal Pain. Case Reports in Surgery. https://doi.org/10.1155/2024/6032042
