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Silencing of CXCR4 Blocks Breast Cancer Metastasis
Open accessAbstract
RNA interference technology, silencing targeted genes in mammalian cells, has become a powerful tool for studying gene function. For the first time in cancer research, we show that direct injection of a pool of naked small interfering RNA (siRNA) duplexes can prevent tumorigenesis in an animal model, suggesting a novel preventive and therapeutic strategy for cancer management. As a model system, we used siRNA duplexes of CXCR4 to block breast cancer metastasis. Here, we show that blocking CXCR4 expression at the mRNA level by a combination of two siRNAs impairs invasion of breast cancer cells in Matrigel invasion assay and inhibits breast cancer metastasis in an animal model. Targeting more than one site of the target gene may be important to overcome the functional redundancy of other variants of a single gene, especially in in vivo experiments. Moreover, our studies confirm the necessity of CXCR4 in breast cancer metastasis.
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Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
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Behlke, M. A. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.01.001 · Cited by 677
Role of hypoxia-inducible factors in breast cancer metastasis
Gilkes, D. M., & Semenza, G. L. (2013) · Future Oncology · doi:10.2217/fon.13.92 · Cited by 274
The Novel Role of the Mu Opioid Receptor in Lung Cancer Progression: A Laboratory Investigation
Mathew, B., Lennon, F. E., Siegler, J., Mirzapoiazova, T., Mambetsariev, N., Sammani, S., Gerhold, L. M., LaRiviere, P. J., Chen, C.-T., Garcia, J. G. N., et al. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31820568af · Cited by 258
Metadata
- Authors
- Liang, Z., Yoon, Y., Votaw, J., Goodman, M. M., Williams, L., & Shim, H.
- Venue
- Cancer Research
- Published
- 2005-02-01
- Volume
- 65
- Issue
- 3
- Pages
- 967-971
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W1809740262
- Cited by
- 402
- References
- 1
- FWCI
- 14.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Liang, Z., Yoon, Y., Votaw, J., Goodman, M. M., Williams, L., & Shim, H. (2005). Silencing of CXCR4 Blocks Breast Cancer Metastasis. Cancer Research. https://doi.org/10.1158/0008-5472.967.65.3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
