The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Identification of a Novel Estrogen Response Element in the Breast Cancer Resistance Protein ( ABCG2 ) Gene
Abstract
The breast cancer resistance protein (BCRP) is an ATP-binding cassette half transporter that confers resistance to anticancer drugs such as mitoxantrone, anthracyclines, topotecan, and SN-38. Initial characterization of the BCRP promoter revealed that it is TATA-less with 5 putative Sp1 sites downstream from a putative CpG island and several AP1 sites (K. J. Bailey-Dell et al., Biochim. Biophys. Acta, 1520: 234–241, 2001). Here, we examined the sequence of the 5′-flanking region of the BCRP gene and found a putative estrogen response element (ERE). We showed that estrogen enhanced the expression of BCRP mRNA in the estrogen receptor (ER)-positive T47D:A18 cells and PA-1 cells stably expressing ERα. In BCRP promoter-luciferase assays, sequential deletions of the BCRP promoter showed that the region between −243 and −115 is essential for the ER effect. Mutation of the ERE found within this region attenuated the estrogen response, whereas deletion of the site completely abrogated the estrogen effect. Furthermore, electrophoretic mobility shift assays revealed specific binding of ERα to the BCRP promoter through the identified ERE. Taken together, we provide evidence herein for a novel ERE in the BCRP promoter.
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Cites
Zhou, S., Schuetz, J. D., Bunting, K. D., Colapietro, A.-M., Sampath, J., Morris, J. J., Lagutina, I., Grosveld, G. C., Osawa, M., Nakauchi, H., et al. (2001) · Nature Medicine · doi:10.1038/nm0901-1028 · Cited by 2,280
Cited by
Lowery, A. J., Miller, N., Devaney, A., McNeill, R. E., Davoren, P. A., Lemetre, C., Benes, V., Schmidt, S., Blake, J., Ball, G., et al. (2009) · Breast Cancer Research · doi:10.1186/bcr2257 · Cited by 450
ABC Transporters, Drug Resistance, and Cancer Stem Cells
Dean, M. (2009) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-009-9109-9 · Cited by 425
Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance
Natarajan, K., Xie, Y., Baer, M. R., & Ross, D. D. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.01.002 · Cited by 405
Self-citationPan, Y.-Z., Morris, M. E., & Yu, A.-M. (2009) · Molecular Pharmacology · doi:10.1124/mol.108.054163 · Cited by 309
Moitra, K., Lou, H., & Dean, M. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.14 · Cited by 279
Metadata
- Authors
- Ee, P. L. R., Kamalakaran, S., Tonetti, D., He, X., Ross, D. D., & Beck, W. T.
- Venue
- Cancer Research
- Published
- 2004-02-15
- Volume
- 64
- Issue
- 4
- Pages
- 1247-1251
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2104409728
- Cited by
- 217
- References
- 1
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ee, P. L. R., Kamalakaran, S., Tonetti, D., He, X., Ross, D. D., & Beck, W. T. (2004). Identification of a Novel Estrogen Response Element in the Breast Cancer Resistance Protein ( ABCG2 ) Gene. Cancer Research. https://doi.org/10.1158/0008-5472.can-03-3583
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