The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
RETRACTED: Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN) Has Nuclear Localization Signal–Like Sequences for Nuclear Import Mediated by Major Vault Protein
Abstract
Although phosphatase and tensin homologue deleted on chromosome 10 (PTEN) localization in the nucleus and cytoplasm is established, the mechanism is unknown. PTEN is a tumor suppressor phosphatase that causes cell cycle arrest and/or apoptosis. Nuclear-cytoplasmic compartmentalization may be a novel mechanism in regulating these events. PTEN does not contain a traditional nuclear localization sequence (NLS); however, we identified putative NLS-like sequences, which we analyzed by site-directed mutagenesis and localization studies in MCF-7 cells. Two double site mutations exhibited nuclear localization defects. Furthermore, unlike wild-type PTEN, double NLS mutant PTEN did not interact with major vault protein (MVP), a previously hypothesized nuclear-cytoplasmic transport protein. We conclude that these two NLS-like sequences are required for PTEN nuclear import that is mediated by MVP. Further, we show that this MVP-mediated nuclear import is independent of PTEN phosphorylation and of the lipid and protein phosphatase activities of PTEN.
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Citations
Cites
Protean PTEN: Form and Function
Waite, K. A., & Eng, C. (2002) · The American Journal of Human Genetics · doi:10.1086/340026 · Cited by 457
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Cited by
Haddadi, N., Lin, Y., Travis, G., Simpson, A. M., Nassif, N. T., & McGowan, E. M. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0803-3 · Cited by 312
Chang, C.-J., Mulholland, D. J., Valamehr, B., Mosessian, S., Sellers, W. R., & Wu, H. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00310-08 · Cited by 155
PTEN in the maintenance of genome integrity: From DNA replication to chromosome segregation
Hou, S., Ouyang, M., Brandmaier, A., Hao, H., & Shen, W. H. (2017) · BioEssays · doi:10.1002/bies.201700082 · Cited by 65
Metadata
- Authors
- Chung, J.-H., Ginn-Pease, M. E., & Eng, C.
- Venue
- Cancer Research
- Published
- 2005-05-15
- Volume
- 65
- Issue
- 10
- Pages
- 4108-4116
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2058068390
- Cited by
- 164
- References
- 1
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- closed
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- CoChat. (2026). Citation check: RETRACTED: Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN) Has Nuclear Localization Signal–Like Sequences for Nuclear Import Mediated by Major Vault Protein. https://app.cochat.ai/papers/10.1158/0008-5472.can-05-0124
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- Chung, J.-H., Ginn-Pease, M. E., & Eng, C. (2005). RETRACTED: Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN) Has Nuclear Localization Signal–Like Sequences for Nuclear Import Mediated by Major Vault Protein. Cancer Research. https://doi.org/10.1158/0008-5472.can-05-0124
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