The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Reassessing Epithelial to Mesenchymal Transition as a Prerequisite for Carcinoma Invasion and Metastasis
Abstract
For most carcinomas, progression toward malignancy is accompanied by loss of epithelial differentiation and a shift towards a mesenchymal phenotype. This process, referred to as epithelial to mesenchymal transition (EMT), exacerbates motility and invasiveness of many cell types and is often considered a prerequisite for tumor infiltration and metastasis. However, there are numerous examples of advanced carcinomas that adopt some mesenchymal features, yet retain characteristics of well-differentiated epithelial cells. We provide a review of these reports and describe mechanisms to explain the morphologic and molecular heterogeneity and plasticity of malignant carcinoma cells, including incomplete EMT, reversion to an epithelial phenotype, and collective migration. We suggest that these mechanisms can manifest in a series of independent and reversible steps and that EMT represents just one mechanism in the global metastatic carcinoma development process. (Cancer Res 2006; 66(17): 8319-26)
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Cites
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Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
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JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA
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Epithelial–mesenchymal transitions in development and pathologies
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Epithelial-Mesenchymal Transitions
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The Two-Handed E Box Binding Zinc Finger Protein SIP1 Downregulates E-Cadherin and Induces Invasion
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Cited by
Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
Peinado, H., Olmeda, D., & Cano, A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2131 · Cited by 3,121
Collective cell migration in morphogenesis, regeneration and cancer
Friedl, P., & Gilmour, D. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2720 · Cited by 2,712
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
Friedl, P., & Alexander, S. (2011) · Cell · doi:10.1016/j.cell.2011.11.016 · Cited by 1,940
Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
Morel, A.-P., Lièvre, M., Thomas, C., Hinkal, G., Ansieau, S., & Puisieux, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002888 · Cited by 1,645
Classifying collective cancer cell invasion
Friedl, P., Locker, J., Sahai, E., & Segall, J. E. (2012) · Nature Cell Biology · doi:10.1038/ncb2548 · Cited by 963
Metadata
- Authors
- Christiansen, J. J., & Rajasekaran, A. K.
- Venue
- Cancer Research
- Published
- 2006-09-01
- Volume
- 66
- Issue
- 17
- Pages
- 8319-8326
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2082055110
- Cited by
- 1,046
- References
- 83
- FWCI
- 20.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Christiansen, J. J., & Rajasekaran, A. K. (2006). Reassessing Epithelial to Mesenchymal Transition as a Prerequisite for Carcinoma Invasion and Metastasis. Cancer Research. https://doi.org/10.1158/0008-5472.can-06-0410
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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